Generated by All in One SEO Pro v5.0.1.1, this is an llms-full.txt file, used by LLMs to index the site. # Feiolix® Metabolic Health Support ## Posts ### [Shake It Off® with Feiolix®](https://feiolix.com/shake-it-off-with-feiolix/) **Published:** August 24, 2026 **Author:** anagenix **Content:** Why Your Menopause Weight Management Strategy Needs a New Hero: Meet Feiolix® For many women in peri- and post-menopause, old weight loss strategies simply stop working. Hormonal shifts can lead to stubborn "meno-belly," insulin resistance, and a sluggish metabolism that doesn't respond to traditional dieting or exercise. **MenoMe® Shake It Off®** is designed to address these specific metabolic changes using its hero ingredient: **Feiolix®**. What is Feiolix®? Feiolix® is a clinically-proven, patented whole fruit powder derived from premium New Zealand feijoas. Unlike standard fruit extracts, Feiolix® is standardised to preserve the fruit's full bioactive matrix, specifically focusing on its high concentration of **Abscisic Acid (ABA)**. How Feiolix® Supports Menopause Metabolism Feiolix® acts as a natural "gut-led metabolic ally" through several key biological pathways: - - **Natural GLP-1 Support:** Feiolix® is a natural GLP-1 agonist, stimulating the body's endogenous GLP-1 production. This hormone helps increase satiety (feeling full), delays gastric emptying, and regulates blood sugar levels. - **Insulin Sensitivity:** It contains high levels of ABA, which enhances insulin secretion and improves how muscle cells absorb glucose, helping to combat the insulin resistance often seen in menopause. - **Managing Cravings and Hunger:** By promoting satiety and reducing post-meal glucose crashes, Feiolix® helps manage feelings of hunger and intense cravings. - **Reduced Glucose Peaks:** Research shows Feiolix® can significantly smooth post-meal glucose curves, reducing breakfast glucose peaks by up to ~35% and high-GI snack peaks by up to ~50%. - **Anti-Inflammatory Benefits:** It contains ellagitannins, which have an anti-inflammatory effect that helps restore appetite regulation and maintain insulin sensitivity. The Shake It Off® Advantage While Feiolix® handles the metabolic heavy lifting, **Shake It Off®** also includes **Chromium**, an essential trace mineral that further supports healthy metabolism and blood sugar balance. This combination offers a "menopause-first" approach, helping you move away from restrictive dieting and toward long-term lifestyle changes that actually work for your changing body. Whether you are struggling with "meno-belly," frustration with shifting clothes, or a sudden loss of energy, Feiolix® provides the metabolic support needed to feel like yourself again. [Product link](https://www.meno-me.com/product/shake-it-off-with-feiolix/) [![](https://feiolix.com/wp-content/uploads/2026/08/SIO-6-bundle.jpg "SIO-6-bundle")](https://feiolix.com/wp-content/uploads/2026/08/SIO-6-bundle.jpg) [![](https://feiolix.com/wp-content/uploads/2026/08/SIO-HERO-PDP-3-819x1024-1.jpg "SIO-HERO-PDP-3-819×1024")](https://feiolix.com/wp-content/uploads/2026/08/SIO-HERO-PDP-3-819x1024-1.jpg) [![](https://feiolix.com/wp-content/uploads/2026/08/SIO-model-product-1-853x1024-1.png "SIO-model-product-1-853×1024")](https://feiolix.com/wp-content/uploads/2026/08/SIO-model-product-1-853x1024-1.png) **Categories:** Uncategorized --- ### [GLP-1 Crave Control](https://feiolix.com/glp-1-crave-control/) **Published:** August 19, 2026 **Author:** anagenix **Content:** ## Meet the New Zealand Superfruit Switching Off Your Cravings Naturally We have all been there. It is 3 p.m., you are staring into the pantry, and that persistent “food noise” is telling you to grab something sweet. Up to 97% of women say daily cravings derail their best intentions. It is exhausting, but it is not your fault. The body’s natural appetite control system, driven by a hormone signal called GLP-1, can easily get hijacked by daily stress, processed foods, and age. When GLP-1 pathways are working correctly, you easily stop eating when you are full, skip the afternoon sugar spiral, and completely forget about snacks between meals. If you are ready to reclaim control of your appetite without resorting to synthetic medications, painful injections, or extreme restriction, it is time to look to nature. Specifically, to a powerful New Zealand superfruit featured in a breakthrough wellness drink. The Secret in the Cup: Feiolix® Feijoa Powder The team at Evva formulated **GLP-1 Crave Control** to work directly with human biology. One of the foundational hero ingredients in their formula is **Feiolix®**, a premium, 100% natural feijoa whole-fruit powder grown right in the pristine orchards of New Zealand. Feijoa is a beloved, tangy green fruit famous for its rich aromatic flavour and deep wellness properties. When carefully dried into Feiolix® powder, it acts as a cellular powerhouse for the metabolism. Here is exactly how Feiolix® transforms a daily wellness routine inside Evva’s **GLP-1 Crave Control**: - - **Balances Blood Sugar:** Feiolix® helps keep blood glucose steady after eating. No huge insulin spikes mean no aggressive energy crashes later in the day. - **Ignites Metabolism:** It works alongside the body’s natural biology to optimize how hunger is processed and how fat is stored, keeping the metabolic engine running smoothly. - **Calms Inflammation:** Packed with natural defense markers and antioxidants, this whole-fruit superblend actively soothes the gut and reduces internal inflammation. **A Complete, Science-Backed Superblend** Feiolix® does not work alone. Evva blended this incredible New Zealand superfruit powder with other clinically proven, premium ingredients to tackle appetite dysfunction from every angle: - - **Satiereal™ Saffron:** Clinically proven to reduce snacking events by 55% and lower sugar cravings by 78%. - **Inulin Prebiotics & Probiotics:** Feeds the gut microbiome to naturally trigger internal “I’m full” signals. - **Chromium Picolinate:** Balances insulin response to put a stop to intense carb urges. - **Grains of Paradise & Green Tea Extract:** Gently fires up the metabolic furnace to increase the calories burned at rest by up to 17%. **What Real Women Are Saying** There is no need to swallow a handful of pills or force down chalky shakes. **GLP-1 Crave Control** mixes easily into a crisp, delicious peach iced tea that can be enjoyed every morning or early afternoon. Women are already experiencing life-changing results: *“The best way to describe this product is it has ‘turned off the food noise’ in my head, that pesky little voice that was constantly nagging and telling me to grab a snack!! The cravings have pretty much disappeared.”*, Rose W. *“I am craving ‘proper’ healthy food and not snacks/high fat sugar content. My bloating is down. I feel lighter and healthier.”*– Monique **Reclaim Your Vitality** Real transformation takes time. While most women notice a shift in food noise within the first 2 to 3 weeks, Evva recommends enjoying this daily peach iced tea consistently for 8 to 12 weeks to let Feiolix® and the other botanical activators fully restore natural metabolic pathways. No synthetic hormones. No nasty side effects. Just the body, working exactly the way nature intended. [Product link](https://drinkevva.com/products/glp-1-crave-control) [![Person facing away with a black sports top; an orange Crave Control supplement pouch is taped to their lower back against a yellow background.](https://feiolix.com/wp-content/uploads/2026/08/12.webp "12")](https://feiolix.com/wp-content/uploads/2026/08/12.webp) [![Assorted Eviva supplement pouches on a yellow surface with raspberries and citrus slices nearby.](https://feiolix.com/wp-content/uploads/2026/08/Evva_-_Product_Images_3.webp "Evva_-_Product_Images_3")](https://feiolix.com/wp-content/uploads/2026/08/Evva_-_Product_Images_3.webp) [![Supplement facts panel with ingredients and amounts; side badges show Vegan, Gluten Free, Dairy Free and No Added Sugar](https://feiolix.com/wp-content/uploads/2026/08/Evva_Crave_Control_Powder_NIP.webp "Evva_Crave_Control_Powder_NIP")](https://feiolix.com/wp-content/uploads/2026/08/Evva_Crave_Control_Powder_NIP.webp) **Categories:** Uncategorized --- ### [Just Gimme. Better Control](https://feiolix.com/just-gimme-better-control/) **Published:** August 18, 2026 **Author:** anagenix **Content:** **Take Back Control of Your Gut: Spotlight on Just Gimme Better Control** Unpredictable digestive distress can derail your day. Whether you are navigating irregular bowel movements, sudden cramps, or general digestive instability, restoring order to your gut requires targeted care. **Just Gimme Better Control** by Just Gimme Health is formulated to help stabilise your system so you can feel confident and comfortable in your body again. **The Power Player: Feiolix® Feijoa Powder** While kiwi fruit gets plenty of attention, the real secret to targeted digestive regulation in Just Gimme Better Control is **Feiolix®**, a whole-fruit feijoa (pineapple guava) powder sourced directly from New Zealand. Feijoas are naturally rich in bio-active polyphenols, soluble and insoluble dietary fiber, and unique anti-inflammatory compounds that provide comprehensive metabolic and gut support. - **Soothes Gut Irritation:** Feiolix® delivers whole-fruit antioxidants that help calm inflammation along the intestinal lining, reducing sudden bouts of discomfort and cramping. - **Promotes Predictable Regularity:** By delivering natural fruit fiber to support healthy motility and smooth muscle tone, Feiolix® helps restore steady, reliable bowel habits without triggering urgency. - **Balanced Metabolic & Microbial Health:** Beyond digestion, the rich bioactive matrix of feijoa powder aids in maintaining healthy blood sugar balance and supports beneficial gut microbes, strengthening your entire digestive ecosystem. **Reclaim Your Routine** Managing a sensitive gut doesn’t have to mean constant anxiety. By combining the natural restorative properties of Feiolix® feijoa powder with targeted daily nutrition, Just Gimme Better Control gives your system the structure it needs to thrive. [Product link](https://www.justgimmehealth.com/products/just-gimme-better-control) [![Red can with 'just gimme. better control' surrounded by green fruits, berries, and cinnamon sticks.](https://feiolix.com/wp-content/uploads/2026/08/JGBC_Ingredients_Sub-1.webp "JGBC_Ingredients_Sub (1)")](https://feiolix.com/wp-content/uploads/2026/08/JGBC_Ingredients_Sub-1.webp) [![Red promotional bottle with white text reading 'just gimme' and handwritten 'better control,' surrounded by pink sachets on a surface.](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_1.webp "2048px_Web_PDP_11_Jan_2025_1")](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_1.webp) [![Red metal canister labeled 'just gimme. better control'—a craving-control supplement on a neutral background](https://feiolix.com/wp-content/uploads/2026/08/EDITED-15.webp "EDITED-15")](https://feiolix.com/wp-content/uploads/2026/08/EDITED-15.webp) [![Infographic about a blind test on 100 women: 87% felt less lethargic, 84% no sugar cravings, 60% weight loss after 14 days, with packaging photos below.](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_5.webp "2048px_Web_PDP_11_Jan_2025_5")](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_5.webp) [![Nutritional information label showing: Serving size 2g; per 100g: 357 kcal, 0 g fat, 85.2 g carbs (8.5 g sugars), 0.8 g protein, 5 mg sodium, 6.6 g fibre; per serving (2g): 7 kcal, 0 g fat, 1.7 g carbs (0.2 g sugars), 0 g protein, 0.1 mg sodium, 0.1 g fibre; 30 servings per tin.](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_2.webp "2048px_Web_PDP_11_Jan_2025_2")](https://feiolix.com/wp-content/uploads/2026/08/2048px_Web_PDP_11_Jan_2025_2.webp) [![Infographic panel titled The Ingredients showing six circular icons: Feijoa fruit, Mix Berries, Gymnema Sylvestra Extract, Cinnamon Extract, Green Tea Extract, and Okra Extract over a fruit-background sheet.](https://feiolix.com/wp-content/uploads/2026/08/2_6f6655fe-3231-4471-b2cc-c61a173b17a7.webp "2_6f6655fe-3231-4471-b2cc-c61a173b17a7")](https://feiolix.com/wp-content/uploads/2026/08/2_6f6655fe-3231-4471-b2cc-c61a173b17a7.webp) [![The Benefits infographic showing four icons: a crossed-out donut for Reduces Sugar Cravings, a belt-wearing stomach for Supports Appetite Control & Satiety, a fiery bomb for Boosts Metabolism & Fat Utilisation, and a circle with three dots labeled And More.](https://feiolix.com/wp-content/uploads/2026/08/3.webp "3")](https://feiolix.com/wp-content/uploads/2026/08/3.webp) **Categories:** Uncategorized --- ### [Discover Feiolix®: Nature's Answer to Metabolic Health](https://feiolix.com/discover-feiolix-2/) **Published:** October 8, 2024 **Author:** anagenix **Content:** # Discover Feiolix®: Nature’s Answer to Metabolic Health ### **The GLP-1 Connection: Your Body’s Natural Ally** You may have heard about GLP-1 in the news lately, especially in relation to weight management. **GLP-1** (Glucagon-Like Peptide-1) is a hormone that plays a crucial role in regulating blood sugar levels and appetite. When food enters the small intestine, GLP-1 is secreted by L-cells in the gut, triggering several important effects: 1. **Insulin secretion**: GLP-1 stimulates the pancreas to release insulin, helping to lower blood sugar levels. 2. **Glucagon suppression**: It inhibits the release of glucagon, a hormone that raises blood sugar. 3. **Slowed gastric emptying**: GLP-1 delays the rate at which food leaves the stomach, promoting a feeling of fullness. 4. **Appetite reduction**: It acts on the brain to decrease hunger and food intake. These combined effects make GLP-1 a powerful tool in managing weight and blood sugar levels. This is why GLP-1 receptor agonists like Ozempic have become popular for treating type 2 diabetes and obesity[.](https://www.medicalnewstoday.com/articles/how-semaglutide-and-similar-drugs-act-on-the-brain-and-body-to-reduce-appetite) ### **Abscisic Acid: The Hidden Gem in Feiolix** ![Abscisic acid (ABA)](https://feiolix.com/wp-content/uploads/2024/10/A102.png) This is where **abscisic acid** (ABA) comes into play. Found naturally in fruits and vegetables, ABA has been shown to stimulate the secretion of GLP-1. Here’s the kicker: feijoas contain the highest concentration of ABA among all fruits and vegetables, with an impressive 4.29 mg/kg.Abscisic acid is not just a plant hormone – it’s also produced in small amounts in human cells. In our bodies, ABA has several important functions: - **Insulin Sensitivity**: ABA can improve insulin sensitivity and glucose tolerance, similar to the effects of insulin itself. - **Anti-inflammatory effects**: It can reduce inflammation in various tissues, which may contribute to improved metabolic health - **Thermogenesis**: ABA may increase energy expenditure by promoting the conversion of white fat to brown fat, which burns more calories - **GLP-1 stimulation**: ABA has been shown to stimulate the secretion of GLP-1 from intestinal L-cells. This means that ABA can help increase your body’s natural GLP-1 production. - **Dual Action**: Interestingly, there’s a positive feedback loop between ABA and GLP-1. While ABA stimulates GLP-1 secretion, GLP-1 also stimulates ABA release from pancreatic cells. - **Highest Natural Concentration**: Feijoas have the highest concentration of ABA among fruits and vegetables, making Feiolix an exceptionally rich source of this beneficial compound. ### **Feiolix: Harnessing the Power of Feijoa** ![](https://feiolix.com/wp-content/uploads/2024/10/Feijoas.jpg) Feiolix isn’t just another fruit powder. It’s a concentrated source of ABA, with feijoas containing the highest concentration among fruits and vegetables. This makes Feiolix a unique and potent supplement for supporting metabolic health. Feiolix is a whole fruit powder made from New Zealand feijoas, standardized to contain more than 4 mg/100g of ABA. By incorporating Feiolix into your diet, you’re giving your body a natural boost of ABA, which in turn can help: 1. **Increase insulin secretion** from pancreatic β cells 2. **Enhance glucose absorption** by skeletal muscle cells 3. **Regulate metabolism** by decreasing inflammation and increasing GLP-1 secretion 4. **Increase satiety**, helping you feel fuller for longer 5. **Boost postprandial thermogenesis**, potentially reducing weight gain ![](https://feiolix.com/wp-content/uploads/2024/10/F001.jpg) ### **The Science Behind Feiolix** In a preclinical study, mice on a high-fat diet were given Feiolix at different dosages. The results were impressive: Feiolix at a low dose of 300 mg per day was as effective as metformin (a diabetes medication) in significantly reducing elevated fasting blood glucose, triglycerides, total cholesterol, and LDL cholesterol ![](https://feiolix.com/wp-content/uploads/2024/10/f002.jpg) ### **A Three-Pronged Approach** What makes Feiolix truly unique is its triple mechanism of action: 1. **ABA-induced GLP-1 secretion**: The high ABA content stimulates your body’s natural GLP-1 production. 2. **Gut microbiome support**: Feiolix contains dietary fibers that promote the growth of beneficial gut bacteria, which in turn can trigger GLP-1 secretion 3. **Polyphenol GLP**–**1 Secretion**: Recent research has shown that polyphenols such as the catechins present in Feiolix are capable of inducing GLP-1 secretion in addition to lower inflammation in the brain to stop disruptive hunger signals ![](https://feiolix.com/wp-content/uploads/2024/10/f003.jpg) ![](https://feiolix.com/wp-content/uploads/2024/10/f004.jpg) ### **The Gut Microbiome: Your Inner Ecosystem** Feiolix contains dietary fibers that act as prebiotics, nourishing beneficial gut bacteria. These bacteria, in turn, produce compounds that can further stimulate GLP-1 production, creating a virtuous cycle of metabolic support. ![](https://feiolix.com/wp-content/uploads/2024/10/f005.jpg) ### **The Science Behind Feiolix** Our research has shown that Feiolix can promote the growth of various probiotics by up to over 300% compared to control groups. This synbiotic effect underscores Feiolix’s potential as a comprehensive supplement for metabolic and gut health. **Beyond Blood Sugar: A Holistic Health Boost** Feiolix’s benefits extend far beyond blood sugar control. Our research suggests that it may also: - Help reduce triglycerides and cholesterol levels - Increase insulin secretion from pancreatic cells - Enhance glucose absorption by muscle cells - Reduce inflammation - Increase feelings of fullness after meals ### **The Bottom Line and What this Means for you** If you’re looking for a natural way to support your weight loss efforts, Feiolix offers a promising solution. By harnessing the power of abscisic acid and supporting your gut microbiome, it may help you achieve your weight loss goals without the need for synthetic medications. Remember, while Feiolix shows great potential, it’s always best to consult with a healthcare professional before starting any new supplement regimen. #### **References:** 1. Anagenix. “What is GLP-1” Factsheet, August 2024. 2. Bruzzone S, Magnone M, Mannino E, Sociali G, Sturla L, Fresia C, et al. (2015) Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats. PLoS ONE 10(10): e0140588. doi:10.1371/journal.pone.0140588 3. Bruzzone S, Ameri P, Briatore L, Mannino E, Basile G, Andraghetti G, et al. The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts. FASEB J (2012) 26(3):1251-60. doi:10.1096/f.11-190140 4. Zocchi E, Hontecillas R, Leber A, Einerhand A, Carbo A, Bruzzone S, Tubau-Juni N, Philipson N, Zoccoli-Rodriguez V, Sturla L and Bassaganya-Riera J (2017) Abscisic Acid: A Novel Nutraceutical for Glycemic Control. Front. Nutr. 4:24. doi: 10.3389/fnut.2017.00024 **Categories:** GLP-1, Metabolic Health, Metabolism --- ### [Discover Feiolix®: Nature's Answer to Metabolic Health](https://feiolix.com/discover-feiolix232323/) **Published:** October 8, 2024 **Author:** anagenix **Content:** ## **The GLP-1 Connection: Your Body’s Natural Ally** You may have heard about GLP-1 in the news lately, especially in relation to weight management. **GLP-1** (Glucagon-Like Peptide-1) is a hormone that plays a crucial role in regulating blood sugar levels and appetite. When food enters the small intestine, GLP-1 is secreted by L-cells in the gut, triggering several important effects: 1. **Insulin secretion**: GLP-1 stimulates the pancreas to release insulin, helping to lower blood sugar levels. 2. **Glucagon suppression**: It inhibits the release of glucagon, a hormone that raises blood sugar. 3. **Slowed gastric emptying**: GLP-1 delays the rate at which food leaves the stomach, promoting a feeling of fullness. 4. **Appetite reduction**: It acts on the brain to decrease hunger and food intake. These combined effects make GLP-1 a powerful tool in managing weight and blood sugar levels. This is why GLP-1 receptor agonists like Ozempic have become popular for treating type 2 diabetes and obesity[.](https://www.medicalnewstoday.com/articles/how-semaglutide-and-similar-drugs-act-on-the-brain-and-body-to-reduce-appetite) ### **Abscisic Acid: The Hidden Gem in Feiolix** ![Abscisic acid (ABA)](https://feiolix.com/wp-content/uploads/2024/10/A102.png) This is where **abscisic acid** (ABA) comes into play. Found naturally in fruits and vegetables, ABA has been shown to stimulate the secretion of GLP-1. Here’s the kicker: feijoas contain the highest concentration of ABA among all fruits and vegetables, with an impressive 4.29 mg/kg.Abscisic acid is not just a plant hormone – it’s also produced in small amounts in human cells. In our bodies, ABA has several important functions: - **Insulin Sensitivity**: ABA can improve insulin sensitivity and glucose tolerance, similar to the effects of insulin itself. - **Anti-inflammatory effects**: It can reduce inflammation in various tissues, which may contribute to improved metabolic health - **Thermogenesis**: ABA may increase energy expenditure by promoting the conversion of white fat to brown fat, which burns more calories - **GLP-1 stimulation**: ABA has been shown to stimulate the secretion of GLP-1 from intestinal L-cells. This means that ABA can help increase your body’s natural GLP-1 production. - **Dual Action**: Interestingly, there’s a positive feedback loop between ABA and GLP-1. While ABA stimulates GLP-1 secretion, GLP-1 also stimulates ABA release from pancreatic cells. - **Highest Natural Concentration**: Feijoas have the highest concentration of ABA among fruits and vegetables, making Feiolix an exceptionally rich source of this beneficial compound. ### **Feiolix: Harnessing the Power of Feijoa** ![](https://feiolix.com/wp-content/uploads/2024/10/Feijoas.jpg) Feiolix isn’t just another fruit powder. It’s a concentrated source of ABA, with feijoas containing the highest concentration among fruits and vegetables. This makes Feiolix a unique and potent supplement for supporting metabolic health. Feiolix is a whole fruit powder made from New Zealand feijoas, standardized to contain more than 4 mg/100g of ABA. By incorporating Feiolix into your diet, you’re giving your body a natural boost of ABA, which in turn can help: 1. **Increase insulin secretion** from pancreatic β cells 2. **Enhance glucose absorption** by skeletal muscle cells 3. **Regulate metabolism** by decreasing inflammation and increasing GLP-1 secretion 4. **Increase satiety**, helping you feel fuller for longer 5. **Boost postprandial thermogenesis**, potentially reducing weight gain ![](https://feiolix.com/wp-content/uploads/2024/10/F001.jpg) **The Science Behind Feiolix** In a preclinical study, mice on a high-fat diet were given Feiolix at different dosages. The results were impressive: Feiolix at a low dose of 300 mg per day was as effective as metformin (a diabetes medication) in significantly reducing elevated fasting blood glucose, triglycerides, total cholesterol, and LDL cholesterol ![](https://feiolix.com/wp-content/uploads/2024/10/f002.jpg) **A Three-Pronged Approach** What makes Feiolix truly unique is its triple mechanism of action: 1. **ABA-induced GLP-1 secretion**: The high ABA content stimulates your body’s natural GLP-1 production. 2. **Gut microbiome support**: Feiolix contains dietary fibers that promote the growth of beneficial gut bacteria, which in turn can trigger GLP-1 secretion 3. **Polyphenol GLP**–**1 Secretion**: Recent research has shown that polyphenols such as the catechins present in Feiolix are capable of inducing GLP-1 secretion in addition to lower inflammation in the brain to stop disruptive hunger signals ![](https://feiolix.com/wp-content/uploads/2024/10/f003.jpg) ![](https://feiolix.com/wp-content/uploads/2024/10/f004.jpg) **The Gut Microbiome: Your Inner Ecosystem** Feiolix contains dietary fibers that act as prebiotics, nourishing beneficial gut bacteria. These bacteria, in turn, produce compounds that can further stimulate GLP-1 production, creating a virtuous cycle of metabolic support. ![](https://feiolix.com/wp-content/uploads/2024/10/f005.jpg) **The Science Behind Feiolix** Our research has shown that Feiolix can promote the growth of various probiotics by up to over 300% compared to control groups. This synbiotic effect underscores Feiolix’s potential as a comprehensive supplement for metabolic and gut health. **Beyond Blood Sugar: A Holistic Health Boost** Feiolix’s benefits extend far beyond blood sugar control. Our research suggests that it may also: - Help reduce triglycerides and cholesterol levels - Increase insulin secretion from pancreatic cells - Enhance glucose absorption by muscle cells - Reduce inflammation - Increase feelings of fullness after meals **The Bottom Line and What this Means for you** If you’re looking for a natural way to support your weight loss efforts, Feiolix offers a promising solution. By harnessing the power of abscisic acid and supporting your gut microbiome, it may help you achieve your weight loss goals without the need for synthetic medications. Remember, while Feiolix shows great potential, it’s always best to consult with a healthcare professional before starting any new supplement regimen. References: 1. Anagenix. “What is GLP-1” Factsheet, August 2024. 2. Bruzzone S, Magnone M, Mannino E, Sociali G, Sturla L, Fresia C, et al. (2015) Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats. PLoS ONE 10(10): e0140588. doi:10.1371/journal.pone.0140588 3. Bruzzone S, Ameri P, Briatore L, Mannino E, Basile G, Andraghetti G, et al. The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts. FASEB J (2012) 26(3):1251-60. doi:10.1096/f.11-190140 4. Zocchi E, Hontecillas R, Leber A, Einerhand A, Carbo A, Bruzzone S, Tubau-Juni N, Philipson N, Zoccoli-Rodriguez V, Sturla L and Bassaganya-Riera J (2017) Abscisic Acid: A Novel Nutraceutical for Glycemic Control. Front. Nutr. 4:24. doi: 10.3389/fnut.2017.00024 **Categories:** Uncategorized --- ### [28 DAYS Metabolic Balance](https://feiolix.com/28-days-metabolic-balance/) **Published:** February 17, 2025 **Author:** anagenix **Content:** ### Transforming Metabolic Health with Feiolix® When 28DAYS set out to create a science-backed supplement to support metabolic health, they sought a natural ingredient that could effectively address key metabolic challenges such as blood sugar regulation, inflammation, and weight management. Their search led them to Feiolix®, a powerful whole fruit feijoa powder that is scientifically proven to enhance insulin sensitivity and support metabolic balance. ### The Power of Feiolix® in 28DAYS Metabolic Balance 28DAYS Metabolic Balance is a cutting-edge supplement designed to help individuals maintain a healthy metabolism and improve overall well-being. Powered by Feiolix®, this innovative formula leverages the natural benefits of feijoa, making it a game-changer for those looking to take control of their metabolic health. ![28 days Metabolic Balance](https://feiolix.com/wp-content/uploads/2025/02/1_38.webp "28 days Metabolic Balance") [Product link](https://28days.co.nz/products/metabolic-balance) #### **Why Feiolix®?** Feiolix® was the perfect choice for 28DAYS because of its unique combination of bioactive compounds, including: - **Abscisic Acid**: A natural hormone that enhances GLP-1 action, improving insulin secretion, reducing glucagon secretion, and regulating appetite. - **Xyloglucans**: Plant-based polysaccharides that support bile acid function, promoting balanced blood glucose and triglyceride levels. - **Pedunculagin**: A powerful anti-inflammatory compound that supports brain, heart, liver, and adipose tissue health, all critical in managing metabolic syndrome. ### **Real Results, Backed by Science** With the inclusion of Feiolix®, 28DAYS Metabolic Balance offers key benefits, such as: - **Weight Management**: Supports appetite regulation and prevents excessive weight gain. - **Improved Blood Sugar & Lipid Levels**: Helps normalize blood glucose and triglycerides. - **Anti-Inflammatory Properties**: Targets inflammation across key metabolic organs. ### **Success Beyond the Supplement** 28DAYS is not just a product; it’s a lifestyle shift. By combining Feiolix® with a structured 28-day wellness routine, users are empowered to take charge of their health. With its pure, high-quality ingredients manufactured in New Zealand, 28DAYS Metabolic Balance is setting a new standard in metabolic health solutions. ### **A Future of Innovation** The success of 28DAYS Metabolic Balance has reaffirmed Feiolix® as a transformative ingredient for brands looking to develop metabolic health products. As the demand for natural, science-backed solutions grows, Feiolix® continues to provide brands with the opportunity to create effective, market-leading formulations. With 28DAYS Metabolic Balance, consumers now have a trusted solution that aligns with their health goals—proving that nature and science together can create real impact. **Categories:** Uncategorized --- ### [Full up! Simplifying satiety](https://feiolix.com/full-up-simplifying-satiety/) **Published:** April 21, 2022 **Author:** anagenix **Content:** # Full up! Simplifying satiety ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × When was the last time you felt truly satiated? Not stuffed to the brim, but simply comfortable and content. That may sound simple, but satiety is an incredibly complex sensation, and can be difficult for some people to experience. **We can think of satiety as having three key components, which work together in a tightly regulated feedback loop:** - The physical sensation of fullness, - hormonal signaling of nutrient adequacy, and - sufficient detection and interpretation of these physical and chemical signals in the brain. In the case of the inflammatory condition known as [metabolic syndrome](https://feiolix.com/what-is-metabolic-health/), the balance across these complex feedback loops is lost… but can be restored with a little help. ![](https://feiolix.com/wp-content/uploads/2022/04/satiety.jpeg) Until recently, satiety was almost exclusively thought of as a physical sensation. Countless products have been developed to increase the sensation of fullness or mimic tastes and textures that we crave without increasing calories. Enter non-digestible bulking fibres, non-caloric sweeteners, and emulsifiers. However, it’s become increasingly clear that the physical aspect of satiety is only one piece of the puzzle, albeit an important piece. Critically, some of the products developed to mimic flavors and textures and bulk, don’t necessarily register as *satiating* in our bodies. Our intestines are smarter than we give them credit for and not so easily tricked. Natural fibres, omega-3 fats, and the amino acid glutamate are the primary nutrients detected by chemosensory receptors in the gut, which convert extracellular signals to intracellular responses. Adequate concentrations of nutrients trigger the release of hormones and satiety signals to the vagus nerve and on to the brain, along the gut-brain-axis (Burman 2021). The activity of chemosensory receptors can be changed with other molecules present in the diet or produced by microbes residing in the gut. For instance, the short chain fatty acid propionate, which is produced by several probiotic species of bacteria utilizing dietary fibre from plants, acts on chemosensory receptors and increases the satiety signals sent to the brain. ### **GLP-1 – A Potent Signaling Hormone of Satiety** Signals from the chemosensory receptors aren’t the only hunger and satiety signals moving upwards to the brain; hormones and peptides also get in on the action. Leptin, Ghrelin, Peptide YY (PYY), Cholecystokinin (CCK), Glucagon Like Peptide 1( GLP-1), and Insulin are the major players, but there are also minor players that collectively have a large impact across the enteroendocrine and endocrine systems. ![](https://feiolix.com/wp-content/uploads/2022/04/A-Potent-Signaling-Hormone-of-Satiety.jpeg) ![](https://feiolix.com/wp-content/uploads/2022/04/GLP-1-–-A-Potent-Signaling-Hormone-of-Satiety.jpeg) GLP-1 is one of the most potent signaling hormones of satiety and has anti-inflammatory action throughout the body, which makes it one of the most promising targets for treating systemic metabolic disease. GLP-1 has three major benefits: - Promotes satiety, - promotes sugar utilization (reducing blood sugar levels), and - reduces inflammation that is mediated by NFκB, as is characteristic of rheumatoid arthritis, atherosclerosis, type 2 diabetes, and metabolic syndrome (Brierley 2021). GLP-1 production can be increased by consuming maté, and fruits containing high concentrations of abscisic acid, such as feijoa and figs. ### **Neuroinflammation – A Possible Cause of Metabolic Syndrome** Getting nutrients right, hosting a thriving gut microbiome, and supporting hormone production and reception are key to achieving satiety. But the experience of satiety as we perceive it is actually occurring in the brain. Just like any other tissue in the body, the brain and central nervous system can become inflamed. Acute inflammation in the brain as an immune response to pathogenic infections (encephalitis) can be life threatening. But sub-acute and chronic inflammation of specific regions of the brain (neuroinflammation) is more common, and while not necessarily life threatening, certainly impacts quality of life and is a predictable consequence of and contributing factor to metabolic syndrome (Purkayastha 2013). The hypothalamus is the primary region of the brain that acts as the master regulator of energy balance, metabolism, and metabolic syndrome (Myers 2012). Many neurons from the vagus nerve connect directly into the brainstem and the hypothalamus, conveying signals of satiety from the gut. Crucially, many hormones are able to cross the blood brain barrier and act directly on neurons. Insulin is one such hormone that is transported across the blood brain barrier and acts directly on the hypothalamus (Hampl 2015). A prominent feature of neuroinflammation is insulin resistance in the hypothalamus. Knowing these mechanisms opens up possibilities to address the problem by re-establishing insulin sensitivity. Luckily, inflammation of the central nervous system responds to specific anti-inflammatory phytochemicals and phytohormones that can be consumed in the diet. Many plant bioactive compounds inhibit the translocation of pro-inflammatory NFκB and subsequent production of inflammatory cytokines and reactive oxygen species, thus reducing neuroinflammation as well as inflammation of many tissues throughout the body and re-establishing insulin sensitivity. Recently it’s been shown that abscisic acid is an insulin sensitizer and reduces neuroinflammation while rescuing the expression of insulin receptor substrate that was otherwise impaired by consumption of a high fat diet (Ribes Navarro 2019). Proper insulin signaling in the brain leads to increased satiety (Hallschmid 2012). **Feiolix Promotes GLP-1 and Increases Insulin Sensitivity** It’s clear that achieving satiety is more than just changing how much food we eat. By eating fruits such as feijoas that are high in anti-inflammatory, GLP-1 promoting, and insulin sensitizing phytohormones, as well as propionate promoting dietary fibre, we can support satiety in our brains and bodies. ### **References** Brierley, D.I., Holt, M.K., Singh, A. *et al.* Central and peripheral GLP-1 systems independently suppress eating. *Nat Metab* **3,** 258–273 (2021). https://doi.org/10.1038/s42255-021-00344-4 Burman, A., & Kaji, I. (2021). Luminal Chemosensory Cells in the Small Intestine. *Nutrients*, *13*(11), 3712. Chaudhri, O. B., Salem, V., Murphy, K. G., & Bloom, S. R. (2008). Gastrointestinal satiety signals. *Annu. Rev. Physiol.*, *70*, 239-255.\\ Hallschmid, M., Higgs, S., Thienel, M., Ott, V., & Lehnert, H. (2012). Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women. *Diabetes*, *61* (4) 782-789; **DOI:** 10.2337/db11-1390 Hampl, R., Bičíková, M., & Sosvorová, L. (2015). Hormones and the blood-brain barrier. *Hormone molecular biology and clinical investigation*, *21*(3), 159–164. https://doi.org/10.1515/hmbci-2014-0042 Moran, A. W., Daly, K., Al-Rammahi, M. A., & Shirazi-Beechey, S. P. (2021). Nutrient sensing of gut luminal environment. *The Proceedings of the Nutrition Society*, *80*(1), 29–36. https://doi.org/10.1017/S0029665120007120 Myers, M., Olson, D. Central nervous system control of metabolism. *Nature* **491,** 357–363 (2012). https://doi.org/10.1038/nature11705 Purkayastha, S., & Cai, D. (2013). Neuroinflammatory basis of metabolic syndrome. *Molecular metabolism*, *2*(4), 356-363. Ribes-Navarro, A., Atef, M., Sánchez-Sarasúa, S., Beltrán-Bretones, M. T., Olucha-Bordonau, F., & Sánchez-Pérez, A. M. (2019). Abscisic acid supplementation rescues high fat diet-induced alterations in hippocampal inflammation and IRSs expression. *Molecular neurobiology*, *56*(1), 454-464. **Categories:** Metabolic Health, Metabolism --- ### [Stimulation of insulin](https://feiolix.com/stimulation-of-insulin/) **Published:** April 22, 2022 **Author:** anagenix **Content:** # Stimulation of insulin ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × An estimated 7.3% of the population is affected by Type II Diabetes Mellitus (T2DM), making it one of the most prevalent chronic diseases worldwide. This figure rises to as many as 34% of all adults in some countries. Approximately 1 in 3 adults are prediabetic, and many adults are undiagnosed. Historically, T2DM has been considered a disease that increases with age, but more and more children, teens, and young adults are now being diagnosed with both prediabetes and T2DM. Prediabetes and T2DM are characterized by impaired glucose tolerance and decreased insulin sensitivity. This means that after eating, blood sugar levels increase to above what the body can safely tolerate before pancreatic β cells in the islets of Langerhans respond by secreting insulin. Additionally, in Type II diabetics, this insulin is not as effective at prompting glucose absorption from the blood stream as it is in non-diabetics. This is known as insulin resistance. This cycle of chronic elevated blood glucose leads to nerve damage in the eyes and peripheral limbs, kidney damage, increased risk of stroke and heart attack, and can be part of more widespread imbalanced hormone feedback loops with systemic effects. ![](https://feiolix.com/wp-content/uploads/2022/04/stimulation-of-insulin-feiolix-ft.jpeg) (adapted from https://bmcbiol.biomedcentral.com/ (Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?)) ***Figure: sugar->blood glucose->detection by pancreatic islet of Langerhans β cells-> stimulation of insulin secretion-> absorption of glucose by skeletal muscle from blood*** An oral glucose tolerance test and haemoglobin A1C (HbA1C) are used to diagnose prediabetes and T2DM. Blood sugar levels between 140 and 199, and/or an HbA1C level of 5.7% – 6.4% are considered prediabetic and patients are often advised to make diet and lifestyle changes to prevent further disease progression into T2DM. When blood sugar levels are above 200, and HbA1C levels are above 6.4% a patient is considered to have T2DM. Treatment often includes pharmaceuticals, such as metformin which increases insulin sensitivity, synthetic insulin administration, or pharmaceuticals that stimulate insulin release. While effective, these treatment regimens frequently cause side effects and negatively impact daily life. Recommended dietary changes are intended to reduce the glycemic index of foods consumed by removing simple sugars and highly processed carbohydrates in favor of complex carbohydrates. The more complex a carbohydrate is, the longer it takes to be broken down by amylase enzymes in the body, leading to a lower and slower post-prandial (after eating) blood-glucose peak, and the lower glycemic index it is considered to have. While these dietary changes are crucial to prevent and reverse the progression of T2DM, there are additional dietary modifications that can actively target and support blood glucose homeostasis. #### Top 10 swaps from high glycemic to lower glycemic index foods **High GI foods** **Moderate and Low GI alternatives** Rice milk 86 ± 7 Soy milk 34 ± 4 Cornflakes 81 ± 6 Rolled oats 55 ± 2 White potato mash 78 ± 4 Sweet potato mash 63 ± 6 White wheat bread 75 ± 2 Rye pumpernickel bread 43 ± 2 White rice 73 ± 4 Barley 28 ± 2 Boiled taro 53 ± 2 Boiled carrots 39 ± 4 Banana 51 ± 3 Apple 36 ± 2 Watermelon 76 ± 4 Orange 43 ± 3 Ice cream 51 ± 3 Yogurt (Greek) 11 ± 2 Table sugar 65 ± 0 Stevia 0 These recommendations are based on the glucose-stimulated insulin-secretion pathway, in which glucose in the blood is detected and absorbed by β-cells of the islets of Langerhans, which synthesize and release insulin. Simple glucose-stimulated insulin-secretion is a primary pathway and is well understood, but fatty acids, amino acids, hormones, and various bioactives and pharmaceuticals also influence insulin release. While modulating blood glucose levels by reducing the amount and speed at which glucose enters the bloodstream is an important and effective modification, this pathway can also be used to stimulate insulin secretion at lower levels of blood glucose. Incretin hormones are intestinal hormones which enhance the secretion of insulin. The most active and understood of these incretins are glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide. Pharmaceutical GLP-1 receptor agonists (mimicking GLP-1) and GLP-1 degradation prohibitors (prolonging the life of GLP-1) have been used since 2005 to treat T2DM by stimulating insulin release at lower blood glucose levels. GLP-1 receptor agonists only support gene transcription of insulin in the presence of blood glucose, so there is no risk of hypoglycemia. However, there are also natural dietary components that act as a GLP-1 receptor agonists. The most promising and well understood compound that behaves in this way is abscisic acid (ABA). Another class of food derived compounds that stimulate insulin secretion are urolithins– microbially transformed antioxidants, ellagitannins. ABA is well known as a plant stress hormone involved in fruit ripening and the separation of fruit from stem. The highest concentrations of ABA have been documented in New Zealand feijoa fruits, followed by avocados, citrus, soybeans, figs, bilberries, maize, apricots, apples, and tomatoes. ABA is also produced and released by human pancreatic β-cells, granulocytes and monocytes at very low levels, meaning that this chemical pathway exists in both plants and animals. We humans have receptors (LANCL2) that respond to ABA. #### Top 10 food sources of ABA **Foodstuff** **ABA level (mg/kg)** New Zealand Feijoas 4.29 Avocados 2.0 Citrus 1.25 Soybean 0.79 Fig 0.72 Bilberry 0.4 Maize 0.33 Apricot 0.32 Apple 0.30 Tomato 0.20 Human LANCL2 (lanthionine synthetase C-like 2 proteins) receptors are expressed across innate immune cells, stem cells, β-cells in the pancreas, and muscle cells. In the β-cells in the pancreas (the insulin-secreting cells), ABA binding to the LANCL2 receptors upregulates glucose transporters in skeletal muscle, thereby decreasing blood glucose and increasing muscle glycogen stores for immediate utilization as energy. In addition, ABA binding to the LANCL2 receptors starts a molecular cascade and positive feedback loop that enhances and extends the glucose–induced secretion of insulin. Similarly, consuming foods high in a subclass of ellagitannins called catechins (green tea, apples, and feijoas) leads to the production of urolithins by the gut microbiota. Urolithins bind to an L-type calcium channel on the B cells of the pancreas, leading to an influx of calcium into the cell. This depolarization triggers the secretion of insulin when lower levels of glucose are present. This means that the consumption of foods high in ABA and ellagitannins supports insulin secretion. Support of insulin secretion is crucial for T2DM and prediabetes patients on reduced glycemic diets because these individuals are insulin-insensitive but now must respond to lower peaks of blood glucose which are triggering a lower insulin response than what they are accustomed to. By supporting insulin secretion with ABA and ellagitannins, their response can remain within the normal range. This is why a combination of reduced blood glucose and improved insulin secretion together support better blood glucose management. **Categories:** Insulin --- ### [Ellagitannins and Urolithins](https://feiolix.com/ellagitannins-and-urolithins/) **Published:** April 22, 2022 **Author:** anagenix **Content:** # Ellagitannins and Urolithins ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × ### What are plant tannins and how do they benefit blood glucose? #### **What are** plant **tannins?** Tannins are a large class of plant bioactive molecules that include ellagitannins, proanthocyanidins, gallic acids, and gallotannins. Ellagitannins are the largest group of tannins and are easily hydrolysed into ellagic acid, either in the plant or in the stomach once consumed. The exact function of tannins in plants is unknown, but ecologists think that tannins may be a defense mechanism, effectively deterring some herbivores that might be detrimental to the plant. Another theory is that tannins act as signalling molecules between plants and environments (usually between roots and soils), and just happen to accumulate in the edible parts of the plant. #### **What are** ellagitannins? Ellagitannins are found in specific fruits and nuts and have recently been found to protect against hormone-dependent cancers (e.g. breast and prostate cancer), cardiovascular diseases, and inflammatory metabolic diseases (e.g. obesity, type 2 diabetes). Previously ellagitannins were considered anti-nutrients (substances that block the absorption of nutrients) and largely ignored in nutrition. As our understanding of bioactivity in foods and our own gut microbiomes has evolved, we have come to realize that humans have likely evolved alongside ellagitannins, seeking them for their flavour and perhaps unknowingly relying on them for their functional health support. More than 1000 distinct ellagitannins have been identified in nature but only ~12 of these have received attention as health-promoting components of foods. Berries (*Rubus*) were the first foods to be noted for their particularly high concentrations of ellagitannins, followed by nuts (walnuts, pecans, and chestnuts), pomegranates, guava, and, most recently, members of the *Myrtaceae* family such as Jabuticaba and Feijoa. It is common for ellagitannins to accumulate in the skins or seeds relative to the flesh, and total concentrations may differ from fruit to fruit and throughout the season. Ellagitannins may decrease in relative concentrations as fruits develop, whereas other antioxidant compounds such as anthocyanins, increase sharply at ripening, particularly in skins. ![](https://feiolix.com/wp-content/uploads/2022/04/Ellagitannins-and-Urolithins-What-are-ellagitannins-3.jpeg) #### What happens when we consume ellagitannins? Once consumed, ellagitannins that have been released from plant cells are hydrolysed by stomach acids into free ellagic acid. Both ellagitannins and ellagic acid are generally poorly absorbed, which means the majority of them travel onto the intestines. Ultimately, they are metabolized by specific species of the gut microbiome into urolithins. Urolithins are incorporated into circulation between the gut and the liver (enterohepatic circulation), eventually becoming available to act as hormone analogs in the body. ![](https://feiolix.com/wp-content/uploads/2022/04/Ellagitannins-and-Urolithins-What-happens-when-we-consume-ellagitannins-e1627954574681.jpeg) (García-Villalba, R., Beltrán, D., Espín, J. C., Selma, M. V., & Tomás-Barberán, F. A. (2013). Time course production of urolithins from ellagic acid by human gut microbiota. Journal of agricultural and food chemistry, 61(37), 8797-8806) #### What are the benefits of ellagitannins? **Ellagitannins have been shown to have:** - Anti-inflammatory action - Anti-tumour activity - Anti-microbial action against pathogenic bacteria and fungi ![](https://feiolix.com/wp-content/uploads/2022/04/Ellagitannins-and-Urolithins-What-are-the-benefits-of-ellagitannins.jpeg) (do Carmo, M. A. V., Fidelis, M., de Oliveira, P. F., Feitoza, L. Q., Marques, M. J., Ferreira, E. B., … & Azevedo, L. (2021). Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1, 2 dimethyl hydrazine-induced colon carcinogenesis. Food and Chemical Toxicology, 112287.) #### **What are urolithins and how do they benefit our health?** There are at least 7 urolithin structures produced by different bacteria. Interestingly, the specific combination of microbes in each person’s microbiome (their enterotype) determines which urolithins are produced and therefore which specific benefits the consumer might experience. The unique health benefits of each individual urolithin structure are still being studied, however, It has been found that urolithin A reduces inflammation in the brain, adipose tissue, heart, and liver, and increases mitochondrial function and thermogenesis, which can delay or prevent the onset of diseases such as Alzheimer’s, non-alcoholic fatty liver disease, and type 2 diabetes. ![](https://feiolix.com/wp-content/uploads/2022/04/Ellagitannins-and-Urolithins-What-are-urolithins-and-how-do-they-benefit-our-health.png) (Cortés-Martín, A., García-Villalba, R., González-Sarrías, A., Romo-Vaquero, M., Loria-Kohen, V., Ramírez-de-Molina, A., … & Espín, J. C. (2018). The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. Food & function, 9(8), 4100-4106.) #### **How can you consume more ellagitannins and absorb more Urolithin A?** A concentrated bioactive source of the ellagitannin pedunculagin is found in Anagenix’s high quality freeze-dried feijoa powder, Feiolix. Feiolix can be easily incorporated into convenient product formats including powdered drink mixes, supplements, and tablets, or added directly to yoghurts, spreads, and sauces. ### **References** Atkinson, C. J., Nestby, R., Ford, Y. Y., & Dodds, P. A. A. (2005). Enhancing beneficial antioxidants in fruits: A plant physiological perspective. *Biofactors*, *23*(4), 229-234. Lipińska, L., Klewicka, E., & Sójka, M. (2014). The structure, occurrence and biological activity of ellagitannins: a general review. *Acta Scientiarum Polonorum Technologia Alimentaria*, *13*(3), 289-299. Kiss, A. K., & Piwowarski, J. P. (2018). Ellagitannins, gallotannins and their metabolites-the contribution to the anti-inflammatory effect of food products and medicinal plants. *Current medicinal chemistry*, *25*(37), 4946-4967. Aguilar-Zárate, P., Wong-Paz, J. E., Buenrostro-Figueroa, J. J., Ascacio, J. A., Contreras-Esquivel, J. C., & Aguilar, C. N. (2018). Ellagitannins: bioavailability, purification and biotechnological degradation. *Mini reviews in medicinal chemistry*, *18*(15), 1244-1252. do Carmo, M. A. V., Fidelis, M., de Oliveira, P. F., Feitoza, L. Q., Marques, M. J., Ferreira, E. B., … & Azevedo, L. (2021). Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1, 2 dimethyl hydrazine-induced colon carcinogenesis. *Food and Chemical Toxicology*, 112287. Romo‐Vaquero, M., Cortés‐Martín, A., Loria‐Kohen, V., Ramírez‐de‐Molina, A., García‐Mantrana, I., Collado, M. C., … & Selma, M. V. (2019). Deciphering the human gut microbiome of urolithin metabotypes: association with enterotypes and potential cardiometabolic health implications. *Molecular nutrition & food research*, *63*(4), 1800958. Cortés-Martín, A., García-Villalba, R., González-Sarrías, A., Romo-Vaquero, M., Loria-Kohen, V., Ramírez-de-Molina, A., … & Espín, J. C. (2018). The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. *Food & function*, *9*(8), 4100-4106. García-Mantrana, I., Calatayud, M., Romo-Vaquero, M., Espín, J. C., Selma, M. V., & Collado, M. C. (2019). Urolithin metabotypes can determine the modulation of gut microbiota in healthy individuals by tracking walnuts consumption over three days. *Nutrients*, *11*(10), 2483. Toney, A. M., Fox, D., Chaidez, V., Ramer-Tait, A. E., & Chung, S. (2021). Immunomodulatory Role of Urolithin A on Metabolic Diseases. *Biomedicines*, *9*(2), 192. Pereira, L. D., Barbosa, J. M. G., Ribeiro da Silva, A. J., Ferri, P. H., & Santos, S. C. (2017). Polyphenol and ellagitannin constituents of jabuticaba (Myrciaria cauliflora) and chemical variability at different stages of fruit development. *Journal of agricultural and food chemistry*, *65*(6), 1209-1219. Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., … & Rinsch, C. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. *Nature Metabolism*, *1*(6), 595-603. D’Amico, D., Andreux, P. A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. (2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. *Trends in Molecular Medicine*. García-Villalba, R., Beltrán, D., Espín, J. C., Selma, M. V., & Tomás-Barberán, F. A. (2013). Time course production of urolithins from ellagic acid by human gut microbiota. *Journal of agricultural and food chemistry*, *61*(37), 8797-8806. do Carmo, M. A. V., Fidelis, M., de Oliveira, P. F., Feitoza, L. Q., Marques, M. J., Ferreira, E. B., … & Azevedo, L. (2021). Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1, 2 dimethyl hydrazine-induced colon carcinogenesis. *Food and Chemical Toxicology*, 112287. Xia, B., Shi, X. C., Xie, B. C., Zhu, M. Q., Chen, Y., Chu, X. Y., … & Wu, J. W. (2020). Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. *PLoS biology*, *18*(3), e3000688. Vandana, U. K., Barlaskar, N. H., Gulzar, A. B. M., Laskar, I. H., Kumar, D., Paul, P., … & Mazumder, P. B. (2020). Linking gut microbiota with the human diseases. *Bioinformation*, *16*(2), 196. Xu, J., Yuan, C., Wang, G., Luo, J., Ma, H., Xu, L., … & Li, L. (2018). Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways. *Journal of agricultural and food chemistry*, *66*(3), 571-580. **Categories:** Bioactives --- ### [What is metabolic health?](https://feiolix.com/what-is-metabolic-health/) **Published:** April 23, 2022 **Author:** anagenix **Content:** # What is metabolic health? ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × Staying fit and healthy is a top priority for many people, but health can be defined in many ways and is not necessarily simply being free of illness or injury, or having a “normal” weight. The World Health Organization (WHO) defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.” Clearly, there are many aspects contributing to our overall health. #### One of these aspects is our metabolic health. Metabolism refers to all the chemical processes that are continuously happening within our bodies in order to sustain us, which fall into two broad categories: - **Catabolism** – the process of converting food into energy by breaking down complex structures into smaller components, thus releasing energy - **Anabolism** – the process of capturing that energy and using those smaller components to build up and regenerate our own human structures When people think of metabolism and metabolic health, weight is often the first thing to come to mind. However metabolic health is more complex than just weight and encompasses the risk of heart disease, diabetes and stroke. Whilst there is no standard definition for “metabolic health”, researchers from the University of North Carolina, USA1, used optimal levels of the five biological variables traditionally associated with cardiovascular disease and metabolic syndrome risk to define metabolic health and determine its prevalence. **These variables are:** - Waist circumference - Blood pressure - Blood glucose (including HbA1c) - Blood triglycerides - Cholesterol (high-density lipoprotein (HDL)-C) The researchers determined that metabolically healthy people have optimal levels of all five of these variables. Interestingly, and concerningly, the researchers found that < 20% of American adults were metabolically healthy. This decreased to just 12.2% when the most restrictive cutoff points were used. The researchers noted that an elevated waist circumference alone is only weakly associated with cardiovascular disease risk, but even when this variable was excluded, only one-third of ideal weight (as defined by BMI) adults were considered metabolically healthy. This highlights the need to look beyond the scales when determining metabolic health. Related to “metabolic health” is “metabolic syndrome”. Metabolic syndrome is diagnosed when a person presents with suboptimal levels of 3 out of the 5 biological variables associated with cardiovascular disease risk. It is estimated that around 22–34% of the adult population2,3 has metabolic syndrome and is therefore at risk of developing cardiovascular disease, diabetes or having a stroke. **The risk factors for developing metabolic syndrome include central obesity (i.e. excess fat around the middle), insulin resistance, age, inactivity/sedentary lifestyle and genetics.** ![](https://feiolix.com/wp-content/uploads/2022/04/Complications_of_metabolic_syndrome_Chart.jpeg) ![](https://feiolix.com/wp-content/uploads/2022/04/Complications_of_metabolic_syndrome_Small.jpeg) *Figure 1: Complications/health outcomes that can arise as a result of having metabolic syndrome/poor metabolic health* Closely related to metabolic syndrome and with overlapping aspects is prediabetes. People with prediabetes have elevated blood sugar (glucose) levels, but not high enough to be classed as diabetes (prediabetes: fasting blood glucose of 100 – 125 mg/dL; diabetes: fasting blood glucose of > 125 mg/dL). Prediabetics are often also overweight with central belly fat and have high blood pressure. Prediabetes and metabolic syndrome have also been referred to as inflammatory syndromes and are characterised by hormone imbalance on a biochemical level. Catabolic hormones include adrenaline, cortisol, glucagon, and cytokines, which are predominantly associated with stress and inflammation. Anabolic hormones include insulin, growth hormone, testosterone, and estrogen, which are primarily reproductive. Insulin and glucagon work in concert to maintain blood glucose levels by coordinating the absorption of glucose into tissue such as muscles. Crucially, all of these hormones work together and influence each other in feedback loops to maintain homeostasis. An imbalance in any of these hormones has follow-on effects throughout the system, contributing to excessive weight gain or loss. Through feedback loops, even catabolic reactions using energy such as chronic inflammation lead to increased anabolism and subsequent weight gain. While this complexity can make metabolic syndrome and prediabetes difficult to resolve, it also means that there are multiple entry points through which to address underlying problems and improve metabolic health. #### To improve your metabolic health and reduce the risk of developing metabolic syndrome and associated diseases, you should: 1. **Eat a healthy diet.** Consume a range of high-fibre foods, fruits and vegetables, lean meats and plant proteins, and reduce/avoid your intake of processed foods, sugary foods (particularly those with added sugar) and foods with high levels of saturated fats, trans fats, cholesterol and salt. 2. **Obtain/maintain a healthy weight.** If you are overweight or obese, a loss of around 5-10% can halve your risk of developing metabolic syndrome/diabetes by helping to reduce blood pressure, blood sugar and cholesterol. 3. **Partake in regular physical activity.** This will help to improve blood pressure and cholesterol. Moderately strenuous exercise that makes you breathe harder is best. Aim for around 30 minutes a day / 150 minutes a week. 4. **Don’t smoke.** Smoking can increase blood pressure and insulin resistance. It can also cause inflammation in the body. 5. **Reduce/manage stress.** Chronic stress has been linked to an increased risk of metabolic disease, including obesity, cardiovascular disease and diabetes. 6. **Get regular check-ups.** Early diagnosis of any issues means you can get onto making any required changes sooner and reduce long-term health complications. #### **References:** 1. Araujo, J., Cai J., Stevens J. Prevalence of optimal metabolic health in American adults: national health and nutrition examination survey 2009 – 2016. Metabolic Syndrome and Related Disorders, 2019, 17(1): 46-52 2. American Hearth Association https://www.heart.org/en/health-topics/metabolic-syndrome/about-metabolic-syndrome, accessed 14 April 2021 3. Moore, JX., Chaudhary N, Akinyemiju, T. Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012. Preventing Chronic Disease, 2017, 14: 160287 **Categories:** Metabolic Health --- ### [Feiolix and fats- friend and foe?](https://feiolix.com/feiolix-fats-friend-foe/) **Published:** April 29, 2022 **Author:** anagenix **Content:** # Feiolix and fats- friend and foe? ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × ### Feiolix supports healthy blood lipid profiles Blood sugar tends to take centre stage in Type II diabetes mellitus (T2DM) and [Metabolic Syndrome](https://feiolix.com/), earning itself quite a reputation for dramatic highs and lows and being difficult to manage. But there’s a whole cast and crew of fats and lipid molecules around those dastardly sugar molecules that play major roles in health dramas as well. The relevance of fat metabolism to metabolic health isn’t just in body size and shape, although that can be important as well if visceral fat accumulates around vital organs in the abdomen. Abnormalities in lipid metabolism are clearly identified in the 3/5 of the diagnostic criteria for Metabolic Syndrome relating to blood triglycerides, HDL cholesterol, and LDL cholesterol. This overlaps with the estimated 72-85% of T2DM patients who also have diabetic dyslipidaemia, which is associated with substantially increased risk for cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). ![](https://feiolix.com/wp-content/uploads/2022/04/Cholesterol_levels2_900x506.jpg) It’s been suggested that the dislipidaemia seen in diabetics and metabolic syndrome is due to lifestyle factors such as a high fat diet, but there’s much more going on in terms of how fats are metabolised and the quality and storage of the molecules resulting from that metabolism. The common connection here between dislipidaemia, diabetes and metabolic syndrome is insulin which is the primary director of energy utilisation and metabolism: supporting insulin sensitivity can pull both blood sugar and blood lipids back into balance. **Insulin has two primary effects on lipid metabolism:** 1. Insulin promotes the conversion of **free fatty acids** to **lipoproteins** in the liver when the liver is saturated with **glycogen**. These lipoproteins are then exported back into the blood stream for further utilisation or accumulation. 2. Insulin inhibits the breakdown of **triglycerides** into free fatty acids in **adipose tissue** by inhibiting lipase, leading to accumulation of fat. But this isn’t just a one-way street, free fatty acids in the blood also cause **insulin resistance** in muscle cells by inhibiting insulin-stimulated glucose absorption and glycogen synthesis. Insulin resistance means that cells don’t absorb glucose from the blood stream quickly enough when insulin is released from the pancreas. This leaves both glucose and insulin circulating in the blood which can be dangerous for nerves and the kidneys. Circulating glucose and free fatty acids eventually arrive at the liver. When the liver is presented with excessive fatty acids and insulin, dangerous and atherosclerotic **LDL** and **VLDL** **cholesterols** are produced. This process is controlled by **ApoB**, often considered the gate keeper to danger. Diets high in sugar and fat promote ApoB production. As more ApoB is produced, more free fatty acids are converted into LDL and VLDL, which tend to stick to the inside walls of arteries, leading to atherosclerosis. HDL is termed the good cholesterol because it’s atheroprotective and functions in reverse cholesterol transport: the movement of cholesterol away from peripheral cells and arteries to the liver from catabolism and excretion. HDL contains a lipoprotein called **ApoA-1** which is at the core of this action, making it the gatekeeper to health. Doctors are increasingly looking at the ratio of Apo-B/ApoA-1 to measure a patient’s risk of heart attack. ![](https://feiolix.com/wp-content/uploads/2022/04/Cholesterol_Cycle_900x506.gif) It’s important to note that everyone has a specific and unique metabolic phenotype, especially when it comes to lipid metabolism. Some people carry genes to produce more ApoB, which increases their risk for cardiovascular disease, whereas other people can consume the same diet and lead a similar lifestyle with no ill-effects on their metabolic health. It is still important to maintain insulin sensitivity, and there are many changes we can make to reduce insulin resistance. Things we can do to reduce insulin resistance and improve insulin sensitivity: - **Nutrition**: managing macronutrient ratios and energy consumption is the first line of defence against insulin resistance. - **Sleep**: getting at least 7 hours of high-quality sleep with multiple REM cycles is critical for maintaining insulin sensitivity. Sleep deprivation lasting more than 24 hours seems to impair pancreatic B cell function. - **Exercise**: both cardio and resistance exercise (anaerobic and aerobic) help promote glucose absorption and utilisation in the short term. Over the long term, expression of GLUT4 transporters for the uptake of glucose into cells is also increased, improving insulin sensitivity even on off days. - **Plant bioactives**: Some secondary metabolites and hormones produced in plants have potent insulin sensitising actions. Feiolix contains multiple bioactives that [improve insulin sensitivity](https://feiolix.com/stimulation-of-insulin/) and dislipidaemia associated with metabolic syndrome. Abscisic acid and polyphenols found in Feiolix both promote the browning of white fat, meaning the addition of energy utilising mitochondria to otherwise low energy utilising white adipose cells. Abscisic acid and polyphenols also promote energy usage (thermogenesis) in brown adipose tissue, meaning more free fatty acids and glucose is absorbed and burned, particularly right after a meal. Abscisic acid also stimulates glucose absorption and reduces the need for higher levels of insulin to be secreted from the pancreas. This in turn reduces the production of dangerous LDL and VLDL molecules in the liver. Polyphenols have been found to increase the reverse transport of cholesterol by HDL and ApoA-1, which helps to reduce LDL and VLDL and protect patients from CVD and more serious events. By maintaining a healthy lifestyle, eating a polyphenol rich diet, and supplementing diet with potent bioactive compounds such as those found in Feiolix, it’s possible to improve your blood lipid profile along with overall metabolic health. #### Glossary **Free fatty acids: l**ipid species released from the adipose tissue and several cell types upon lipolysis. Apart from their classical roles in energy supply or as structural components, FFAs are active players in many biological processes. **Triglycerides:** are lipids derived from glycerol and three fatty acids. **Glycogen**: is a multi-branched polysaccharide of glucose that stores energy. **Lipoproteins:** are structures containing both protein and fat that carry cholesterol through the bloodstream. **Cholesterol**: is a sterol, which is a type of lipid. Cholesterols are crucial structural and functional components of healthy cells, but too much cholesterol can increase risk of heart disease. **Chylomicrons**: Large triglyceride rich particles made by the intestine to transport dietary triglcyerides and cholesterol to peripheral tissues and the liver. The size of the chylomicron depends on the amount of fat ingested, but each chylomicron contain several apolipoproteins, as well as a core structural Apo B-48 molecule. **Chylomicron remnants:** As peripheral tissues remove triglycerides from chylomicrons, smaller chylomicron remnants are formed, which are pro-atherogenic. **HDL** High density lipoprotein: HDL, or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke (*anti-atherogenic*). **IDL**: Intermediate density lipoproteins, which are proatherogenic, result from the removal of triglycerides from VLDL **LDL** small dense low density lipoprotein cholesterol LDL, sometimes called “bad” cholesterol, makes up most of your body’s cholesterol. High levels of LDL cholesterol raise your risk for heart disease and stroke (*pro-atherogenic*). LDL particles exist in multiple subclasses which vary by size, density, and lipid content. **VLDL** very low-density lipoprotein cholesterol are large and contain the highest amount of triglycerides. High levels of VLDL can contribute to atherosclerosis, which can make a person more susceptible to heart disease or stroke. Eating more carbohydrates, or sugars, than you burn can lead to excessive amounts of triglycerides and high levels of VLDL in your blood. **ApoB-100**: Apolipoprotein B-100 is a type of VLDL and allows LDLs to attach to specific receptors on the surface of cells, particularly in the liver. Once attached, the receptors transport LDLs into the cell, where they are broken down to release cholesterol. Elevated levels of apo B correspond to elevated levels of LDL-C and to non-HDL-C and are associated with an increased risk of cardiovascular disease (CVD). Elevations may be due to a high-fat diet and/or decreased clearing of LDL from the blood. **ApoA-1**: Apolipoprotein A1 is a major component of HDL particles. ApoA-1 enables efflux of fat molecules from within peripheral cells (arteries and macrophages) for transport to the liver for catabolism and excretion. **White adipose tissue** collects, stores and then releases lipids. White adipose tissue is increasingly recognised an endocrine organ, as it also releases leptin (a satiety hormone), inflammatory cytokines, and molecules that participate in lipid metabolism vascular haemostasis (bleeding). **Brown adipose tissue** is an energy utiliser and essential in generating heat. Brown **adipose tissue contains more mitochondria than white adipose tissue.** #### **References:** ![](https://feiolix.com/wp-content/uploads/2022/04/Protein-Chemistry.jpg) Advances Protein Chemistry 45:303, 1994 Athyros, V.G., Doumas, M., Imprialos, K.P. et al. Diabetes and lipid metabolism. Hormones 17, 61–67 (2018). Boden G. (1999). Free fatty acids, insulin resistance, and type 2 diabetes mellitus. Proceedings of the Association of American Physicians, 111(3), 241–248. Brunzell, J. D., & Ayyobi, A. F. (2003). Dyslipidemia in the metabolic syndrome and type 2 diabetes mellitus. The American journal of medicine, 115 Suppl 8A, 24S–28S. https://doi.org/10.1016/j.amjmed.2003.08.011 Chen, L., Chen, X. W., Huang, X., Song, B. L., Wang, Y., & Wang, Y. (2019). Regulation of glucose and lipid metabolism in health and disease. Science China. Life sciences, 62(11), 1420–1458. Feingold KR. Introduction to Lipids and Lipoproteins. \[Updated 2021 Jan 19\]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext \[Internet\]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305896/ Matacchione, G., Gurău, F., Baldoni, S., Prattichizzo, F., Silvestrini, A., Giuliani, A., … & Sabbatinelli, J. (2020). Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials. Ageing Research Reviews, 61, 101074. Millar, C. L., Duclos, Q., & Blesso, C. N. (2017). Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Advances in nutrition (Bethesda, Md.), 8(2), 226–239. Parhofer K. G. (2015). Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes & metabolism journal, 39(5), 353–362. https://doi.org/10.4093/dmj.2015.39.5.353 **Categories:** Insulin --- ### [Unlocking the Power of GLP-1: Nature's Weight Management Ally](https://feiolix.com/what-is-glp-1/) **Published:** September 24, 2024 **Author:** anagenix **Content:** # Unlocking the Power of GLP-1: Nature’s Weight Management Ally ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × As passionate advocates for harnessing nature’s power to support health and wellness journeys, we’re delving into an exciting topic that’s making waves in the world of metabolism and weight management: GLP-1. This remarkable hormone could be the key to understanding how our bodies regulate appetite and weight, and how we can work with our natural systems to achieve our health goals. **What is GLP-1?** Glucagon-like peptide-1, or GLP-1, is a fascinating hormone produced naturally in your body. It’s part of a complex system that helps regulate appetite, metabolism, and blood sugar levels. GLP-1 is primarily released by specialised cells in your intestines, known as L cells, in response to food intake.When you eat, GLP-1 acts as a powerful messenger, signalling to various parts of your body that it’s time to process nutrients. This hormone is part of a larger family called incretins, which play crucial roles in metabolic regulation. **The Intricate World of Metabolism** Before we delve deeper into GLP-1’s role, let’s take a moment to understand metabolism. Metabolism refers to all the chemical processes that occur within your body to maintain life. These processes include: 1. Breaking down food into energy (catabolism) 2. Using that energy to build and repair tissues (anabolism) 3. Eliminating waste products Your metabolic rate – the speed at which these processes occur – is influenced by various factors, including age, gender, muscle mass, and hormones like GLP-1. **GLP-1 and Metabolism: A Powerful Partnership** GLP-1 is often called an “incretin” hormone because it helps increase insulin production when blood sugar levels rise after a meal. This insulin boost helps your cells absorb glucose more efficiently, keeping your blood sugar in check. But that’s not all – GLP-1 also slows down the rate at which food leaves your stomach, a process known as gastric emptying.Here’s a closer look at how GLP-1 impacts your metabolism: 1. **Blood Sugar Regulation**: GLP-1 stimulates the release of insulin from pancreatic beta cells, but only when blood glucose levels are high. This glucose-dependent action helps prevent dangerous drops in blood sugar. 2. **Glucagon Suppression**: GLP-1 inhibits the release of glucagon, a hormone that raises blood sugar. This dual action on insulin and glucagon helps maintain stable blood glucose levels. 3. **Gastric Motility**: By slowing down gastric emptying, GLP-1 helps spread out the absorption of nutrients, preventing rapid spikes in blood sugar. 4. **Pancreatic Health**: Some studies suggest that GLP-1 may promote the growth and survival of pancreatic beta cells, potentially improving long-term metabolic health. **The Weight Management Connection** Now, let’s explore how GLP-1’s metabolic effects translate to weight management: 1. **Appetite Control**: GLP-1 acts on the hypothalamus, the brain’s hunger control centre, sending signals that you’re satisfied. This can lead to reduced overall food intake and fewer cravings. 2. **Slowed Digestion**: By delaying gastric emptying, GLP-1 can help you feel full with smaller portions. This prolonged feeling of satiety can naturally reduce calorie intake without feelings of deprivation. 3. **Metabolic Boost**: Some research suggests GLP-1 may increase energy expenditure, helping you burn more calories throughout the day. While more studies are needed, this could be an exciting avenue for future weight management strategies. 4. **Blood Sugar Balance**: By improving insulin sensitivity and preventing blood sugar spikes and crashes, GLP-1 can help stabilise energy levels and reduce the cravings often associated with blood sugar fluctuations. 5. **Fat Metabolism**: Emerging research indicates that GLP-1 might influence how the body processes and stores fat, potentially favouring the use of fat for energy rather than storage. ![](https://feiolix.com/wp-content/uploads/2024/09/33232.jpg "Fitness Body Builder Challenge") **Natural Sources of GLP-1 Modulators** Whilst GLP-1-based medications (Ozempic and Wegozy) have gained attention for weight loss, there are natural sources that can support your body’s GLP-1 function: 1. **Fibre-Rich Foods**: Foods high in fibre can stimulate GLP-1 release. **Whole grains**, **legumes**, and **vegetables** are excellent sources. 2. **Protein-Rich Foods**: **Eggs**, **nuts**, and **lean meats** can help increase GLP-1 levels. 3. **Healthy Fats**: **Olive oil** and **avocados** contain monounsaturated fats that may support GLP-1 function. 4. **Fermented Foods**: **Probiotics in yoghurt and kefir** may indirectly support GLP-1 production. 5. **Feijoa/Feiolix**: This unique fruit, popular in New Zealand and Australia contains high levels of **abscisic acid**. Abscisic acid has been shown to enhance insulin secretion and support glucose absorption, stimulating release GLP-1. Remember, sustainable weight management is about more than just one hormone. It’s a complex interplay of nutrition, activity, sleep, and overall well-being. By incorporating these natural GLP-1 supporters into a balanced diet and healthy lifestyle, you can work with your body’s innate wisdom to achieve sustainable health and wellness.Stay tuned for more insights into how nature’s bounty can support your journey to optimal health and vitality! #### **References:** Hira T, Trakooncharoenvit A, Taguchi H, Hara H. Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity. Int J Mol Sci. 2021 Jun 21;22(12):6623. doi: 10.3390/ijms22126623. PMID: 34205659; PMCID: PMC8235588. Bodnaruc AM, Prud’homme D, Blanchet R, Giroux I. Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review. Nutr Metab (Lond). 2016 Dec 9;13:92. doi: 10.1186/s12986-016-0153-3. PMID: 27990172; PMCID: PMC5148911. Abiola JO, Oluyemi AA, Idowu OT, Oyinloye OM, Ubah CS, Owolabi OV, Somade OT, Onikanni SA, Ajiboye BO, Osunsanmi FO, et al. Potential Role of Phytochemicals as Glucagon-like Peptide 1 Receptor (GLP-1R) Agonists in the Treatment of Diabetes Mellitus. *Pharmaceuticals*. 2024; 17(6):736. Leber, A., Hontecillas, R., Tubau-Juni, N. *et al.* Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. *Sci Rep* **10**, 10463 (2020). Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30. PMID: 31767182; PMCID: PMC6812410. Millar, C. L., Duclos, Q., & Blesso, C. N. (2017). Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Advances in nutrition (Bethesda, Md.), 8(2), 226–239. Parhofer K. G. (2015). Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes & metabolism journal, 39(5), 353–362. https://doi.org/10.4093/dmj.2015.39.5.353 **Categories:** GLP-1, Metabolic Health, Metabolism --- ### [GLP-1 Medications: A Deeper Dive into Weight Loss Solutions](https://feiolix.com/glp-1-medications-a-deeper-dive-into-weight-loss-solutions/) **Published:** September 24, 2024 **Author:** anagenix **Content:** # GLP-1 Medications: A Deeper Dive into Weight Loss Solutions ## Email Newsletter Keep up with the latest news, articles and stories from Feiolix by signing up for our monthly email newsletter. Submit Thank you for your message. It has been sent. × There was an error trying to send your message. Please try again later. × **Understanding GLP-1 Receptor Agonists** GLP-1 receptor agonists, such as Ozempic (semaglutide), have gained significant attention in recent years for their impressive weight loss results. While these medications mimic the effects of the naturally occurring GLP-1 hormone in your body, it’s important to understand that they are not identical to the hormone itself. Ozempic and similar drugs are synthetic compounds designed to activate GLP-1 receptors more potently and for a longer duration than the natural hormone. **How GLP-1 Medications Promote Weight Loss** These medications work through multiple mechanisms to promote weight loss: 1. They slow down digestion, helping you feel full for longer periods. 2. They act on brain regions controlling hunger, effectively reducing appetite. 3. By regulating blood sugar levels, they can also help curb cravings. These combined effects lead to reduced calorie intake and subsequent weight loss. **Effectiveness and Weight Loss Expectations** The effectiveness of GLP-1 medications for weight loss has been well-documented, with many individuals losing between 5-15% of their body weight. This weight loss typically occurs gradually over several months, with maximum results often seen around the one-year mark. However, it’s crucial to note that individual results can vary significantly. **Beyond Diabetes: GLP-1 for Non-Diabetic Weight Loss** While originally developed for type 2 diabetes management, some GLP-1 medications have now been approved for weight loss in non-diabetic individuals. For instance, Wegovy, a higher dose formulation of semaglutide, is specifically approved for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity. **Choosing the Right GLP-1 Medication** When it comes to choosing a GLP-1 medication for weight loss, recent studies have shown impressive results with semaglutide (Wegovy) and tirzepatide (Mounjaro). However, the most suitable option should always be determined by a healthcare professional based on individual health needs and goals. **Potential Side Effects and Risks** It’s important to be aware that while these medications can be highly effective, they are not without potential side effects. Common issues include nausea, vomiting, diarrhea or constipation, abdominal pain, headache, and fatigue. More serious, albeit rare, side effects can include pancreatitis, gallbladder problems, and changes in heart rate. Always discuss these risks with your healthcare provider before starting treatment. **Dosage and Administration** GLP-1 medications for weight loss typically start at a low dose and gradually increase over time to minimize side effects. For example, Wegovy begins at 0.25 mg once weekly for the first month, then increases monthly until reaching the maintenance dose of 2.4 mg weekly. It’s crucial to follow your doctor’s prescribed dosage instructions carefully. **Consulting with Healthcare Professionals** If you’re considering a GLP-1 medication or supplement, it’s crucial to discuss it with your healthcare provider first. They can help you weigh the potential risks and benefits, and may suggest more effective, evidence-based alternatives for weight management. **Conclusion: A Holistic Approach to Weight Management** While GLP-1 medications have proven to be effective for weight loss, there’s growing interest in natural alternatives that may support GLP-1 pathways. For those transitioning off GLP-1 medications or seeking more natural options, certain dietary supplements and lifestyle changes may offer promising alternatives. Several natural compounds have shown potential in activating GLP-1 pathways or supporting the body’s own GLP-1 production: 1. Berberine: Some studies suggest it may increase GLP-1 secretion and improve insulin sensitivity. 2. Green tea extract: Contains compounds that may stimulate GLP-1 release. 3. Prebiotics and probiotics: Certain strains have been associated with increased GLP-1 levels. 4. High-fibre foods: Foods rich in fibre, like broccoli, apples, and beans, can help stimulate GLP-1 production. 5. Protein-rich foods: Eggs, nuts, and lean meats may help increase GLP-1 levels. 6. Feijoa: This fruit is particularly high in abscisic acid, which has been shown to activate the GLP-1 pathway. Research indicates that abscisic acid can stimulate GLP-1 secretion from intestinal L-cells and increase plasma GLP-1 levels. As a natural source of this GLP-1 enhancer, feijoa could be a valuable addition to a diet aimed at supporting metabolic health. These natural alternatives, when combined with a balanced diet and regular exercise, may help support weight management efforts for those transitioning off GLP-1 medications or looking for non-prescription options. They could potentially help maintain some of the benefits experienced with GLP-1 medications, such as improved appetite control and blood sugar regulation.However, it’s important to note that while these natural options show promise, their effects are generally milder than prescription GLP-1 agonists. They should be viewed as part of a holistic approach to weight management rather than a direct replacement for medications.As always, it’s crucial to consult with a healthcare professional before starting any new supplement regimen, especially when transitioning from prescription medications. They can provide personalized advice, taking into account your individual health needs and goals. Remember, sustainable weight management is a journey that often involves a combination of strategies. By incorporating natural GLP-1 supporters into a healthy lifestyle, you may be able to continue your progress and maintain the benefits you’ve achieved, even after discontinuing GLP-1 medications. #### **References:** Müller TD, et al. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019;30:72-130. Nauck MA, Meier JJ. Incretin hormones: Their role in health and disease. Diabetes Obes Metab. 2018;20 Suppl 1:5-21. Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. FDA. FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014. 2021. Frías JP, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021;385(6):503-515. Bettge K, et al. The GLP-1 Receptor Agonists Exenatide and Liraglutide Activate Glucose Transport by an AMPK-Dependent Mechanism. J Mol Med (Berl). 2012;90(11):1327-1336. Wegovy Prescribing Information. Novo Nordisk. 2021. FDA. FDA 101: Dietary Supplements. 2022. **Categories:** GLP-1, Metabolic Health, Metabolism --- ### [Natural Alternatives to Ozempic: A Comprehensive Guide for Metabolic Health and Weight Management](https://feiolix.com/natural-alternatives-to-ozempic/) **Published:** October 7, 2024 **Author:** anagenix **Content:** # Natural Alternatives to Ozempic: A Comprehensive Guide for Metabolic Health and Weight Management In recent years, Ozempic (semaglutide) has gained immense popularity as a treatment for type 2 diabetes and, more recently, for weight loss. While its effectiveness is well-documented, many are searching for natural alternatives that can provide similar metabolic benefits without the potential risks associated with synthetic drugs. This blog will explore the benefits and severe side effects of Ozempic, the rise of natural alternatives, and why they might be a safer, more sustainable option for long-term weight management. ### **Understanding Ozempic: What It Is and How It Works** Ozempic is a GLP-1 (glucagon-like peptide-1) receptor agonist that mimics the effects of the GLP-1 hormone in the body. This hormone is naturally produced in the gut and helps regulate blood sugar levels by increasing insulin secretion, slowing gastric emptying, and signaling the brain to reduce appetite. Initially prescribed for type 2 diabetes management, Ozempic has become a weight loss solution for many, as it promotes a sense of fullness and helps people adhere to a calorie-restricted diet. ### **Benefits of Ozempic** 1. **Effective Weight Loss**: Clinical studies have shown that Ozempic users can lose an average of 14.9% of their body weight over 68 weeks, making it one of the most effective medications available for weight loss. 2. **Metabolic Improvements**: Ozempic helps regulate blood sugar levels, which reduces the risk of type 2 diabetes complications and improves other metabolic markers such as cholesterol and blood pressure. 3. **Appetite Suppression**: It significantly reduces hunger by acting on the brain’s appetite-regulating centers, making it easier for users to stick to a reduced-calorie diet. 4. **Cardiovascular Benefits**: Research suggests Ozempic may reduce the risk of heart attacks, strokes, and other cardiovascular events, particularly in those with diabetes. ![](https://feiolix.com/wp-content/uploads/2024/10/ozempic-te-221018-6ac7e3.webp) **However, while Ozempic offers significant benefits, it is essential to understand the risks involved, especially when it comes to severe side effects.** ### **The Drawbacks of Ozempic** Despite its benefits, Ozempic comes with some downsides: 1. **Side Effects:** Common side effects include nausea, vomiting, diarrhea, and constipation. These can be severe enough to deter some people from continuing the medication. 2. **Administration:** Ozempic is administered via injection, which may be uncomfortable for people who prefer non-invasive treatments. 3. **Long-Term Effects:** As a relatively new drug, the long-term effects of prolonged Ozempic use are still under investigation. 4. **Cost:** Without insurance coverage, Ozempic can be prohibitively expensive, limiting access for some individuals. ### **Severe Side Effects of Ozempic for weight management:** ![](https://feiolix.com/wp-content/uploads/2024/10/Serious-Risks-of-Taking-Ozempic-.png) Despite its efficacy, some of Ozempic’s side effects can be severe, and these have been backed by clinical studies and scientific data. Here are some of the most serious risks associated with Ozempic use: 1. **Pancreatitis**: One of the most alarming potential side effects of Ozempic is acute pancreatitis. Pancreatitis is an inflammation of the pancreas, which can cause symptoms such as severe abdominal pain, nausea, vomiting, and fever. A review published in the journal *Diabetes Care* found an increased risk of pancreatitis in patients using GLP-1 receptor agonists like Ozempic, although the absolute risk remains low. Nonetheless, people with a history of pancreatitis should use this medication with caution. 2. **Thyroid Cancer Risk**: There has been concern about a potential link between GLP-1 receptor agonists and the development of thyroid cancer. Animal studies have shown that semaglutide, the active ingredient in Ozempic, can lead to the formation of thyroid tumours, including medullary thyroid carcinoma (MTC) . While these findings have not been conclusively observed in humans, the FDA has issued warnings about the potential risk. Individuals with a family history of thyroid cancer are advised to avoid Ozempic or discuss the risks with their healthcare provider. 3. **Gallbladder Disease**: Research has also shown that Ozempic can increase the likelihood of gallbladder-related issues, such as gallstones and gallbladder inflammation (cholecystitis). In some cases, these conditions have required surgical intervention. A study published in *JAMA* found that individuals using GLP-1 receptor agonists had a higher incidence of gallbladder-related problems compared to those on placebo. 4. **Hypoglycemia**: Although Ozempic is primarily prescribed to manage blood sugar levels, in some cases, it can lead to hypoglycemia, or dangerously low blood sugar levels, particularly when used in combination with other antidiabetic medications like insulin. Symptoms of hypoglycemia include dizziness, confusion, sweating, and in severe cases, seizures. 5. **Diabetic Retinopathy Complications**: There is evidence suggesting that rapid improvements in blood sugar levels due to drugs like Ozempic may exacerbate diabetic retinopathy in patients with pre-existing diabetes. This complication can lead to worsening vision or even blindness in severe cases. Given these risks, many individuals are seeking natural alternatives to Ozempic for weight management and metabolic health, especially those who are not diabetic but are using Ozempic off-label for weight loss. ## **The Rise of Natural Alternatives: Why They Matter** ![](https://feiolix.com/wp-content/uploads/2024/09/natural-glp-1.jpg) As concerns over the side effects of synthetic medications like Ozempic grow, there has been a surge in interest in natural alternatives that promote metabolic health in a safer and more holistic manner. These alternatives, typically derived from plants and natural compounds, offer a gentler approach to weight management by leveraging the body’s natural metabolic processes. **Benefits of Natural Alternatives** 1. **Fewer Side Effects**: Natural GLP-1 boosters typically come with fewer and less severe side effects compared to synthetic drugs. This makes them a safer option for those looking for long-term weight management solutions. 2. **Holistic Health**: Unlike medications that target a single issue, natural alternatives often provide a broad range of benefits, from improved gut health to better overall well-being. They promote harmony between various bodily systems, helping to manage weight without disrupting other aspects of health. 3. **Sustainability**: Many natural alternatives can be taken long-term without the need for medical supervision. This makes them suitable for individuals who are seeking a lifelong solution to maintaining a healthy weight. 4. **Affordability and Accessibility**: Natural products are often more affordable than prescription medications and don’t require medical oversight, making them more accessible to a broader range of individuals. ## **Natural GLP-1 Boosters: Alternatives to Ozempic** Many everyday foods can enhance the body’s GLP-1 production, promoting satiety and stable blood sugar levels. Below is a list of key foods that have been scientifically shown to boost GLP-1, each with unique benefits: ### 1. **High-Fiber Foods** ![High fibre foods](https://feiolix.com/wp-content/uploads/2024/10/high-fibre.jpg) **Dietary fibre** plays a significant role in increasing GLP-1 levels, as it slows down digestion, which promotes satiety and stimulates GLP-1 secretion. - **Whole Grains**: Oats, barley, quinoa, brown rice, and whole wheat are rich in soluble fibre. Soluble fibre forms a gel-like substance in the gut that slows digestion, stimulates GLP-1 release, and helps regulate blood sugar levels. - **Legumes**: Lentils, chickpeas, black beans, and kidney beans are excellent sources of fibre and protein. Their high fibre content promotes gut health, which in turn enhances GLP-1 secretion. - **Vegetables**: Leafy greens like spinach, kale, and Brussels sprouts, along with broccoli, cauliflower, and carrots, are high in fibre. Their consumption helps promote a healthy gut environment that supports GLP-1 release. ### 2. **Lean Proteins** ![Lean protein](https://feiolix.com/wp-content/uploads/2024/10/main-leanproteinvsprotein.jpg) Protein-rich meals have been shown to increase GLP-1 secretion by slowing down digestion and enhancing feelings of fullness. - **Chicken Breast & Turkey**: These lean meats are high in protein and low in fat, which helps promote satiety and GLP-1 production without adding excess calories. - **Fish**: Salmon, mackerel, and tuna are high in omega-3 fatty acids and lean protein, both of which support healthy digestion and GLP-1 secretion. - **Eggs**: A great source of protein and healthy fats, eggs have been shown to stimulate GLP-1 release and help maintain stable blood sugar levels. ### 3. **Fruits Rich in Polyphenols** ![](https://feiolix.com/wp-content/uploads/2024/10/summer-drops-cherry-berries-wallpaper-preview.jpg) Certain fruits are rich in polyphenols, which have been found to increase GLP-1 secretion and support healthy metabolism. - **Apples**: Rich in fibre and polyphenols, apples help stimulate GLP-1 secretion and promote gut health. - **Berries**: Blueberries, strawberries, and raspberries are loaded with antioxidants and polyphenols, which improve insulin sensitivity and stimulate GLP-1 release. - **Citrus Fruits**: Oranges, grapefruits, and lemons contain flavonoids that enhance GLP-1 secretion and improve metabolic health. ### 4. **Fermented Foods** ![Fermented Foods](https://feiolix.com/wp-content/uploads/2024/10/fermented-foods222.jpg) Fermented foods promote the growth of beneficial gut bacteria, which play a role in GLP-1 secretion. - **Yogurt & Kefir**: These probiotic-rich dairy products help maintain a healthy gut environment, which in turn supports the body’s natural GLP-1 production. - **Sauerkraut & Kimchi**: Fermented vegetables that contain probiotics, which aid digestion and improve the gut microbiome, boosting GLP-1 levels. ### 5. **Healthy Fats** ![](https://feiolix.com/wp-content/uploads/2024/10/healthy-fat.jpg) Monounsaturated and polyunsaturated fats, as well as omega-3 fatty acids, can enhance GLP-1 secretion by promoting satiety and reducing inflammation. - **Fatty Fish**: Salmon, mackerel, sardines, and herring are rich in omega-3s and support healthy digestion and GLP-1 release. - **Avocados**: High in fibre and healthy fats, avocados help regulate appetite and boost GLP-1 levels, which can aid in weight management. - **Olive Oil**: Rich in monounsaturated fats, olive oil has been shown to stimulate GLP-1 secretion and improve overall metabolic health. - **Nuts & Seeds**: Almonds, walnuts, chia seeds, and flaxseeds contain healthy fats and fibre that support satiety and GLP-1 secretion. ### 6. **Herbs and Spices** ![](https://feiolix.com/wp-content/uploads/2024/10/herbs.webp) Several herbs and spices have been shown to increase GLP-1 levels due to their anti-inflammatory and antioxidant properties. - **Turmeric**: Curcumin, the active ingredient in turmeric, has been shown to boost GLP-1 levels and improve insulin sensitivity. - **Ginger**: This powerful anti-inflammatory spice stimulates GLP-1 secretion and supports digestion. - **Cinnamon**: Known for improving insulin sensitivity, cinnamon also enhances GLP-1 secretion, making it beneficial for blood sugar regulation. ### 7. **Beans and Pulses** ![](https://feiolix.com/wp-content/uploads/2024/10/beans.jpg) Beans and pulses are rich in both fibre and protein, making them excellent natural GLP-1 boosters. - **Black Beans**: High in fibre and protein, black beans help increase satiety and promote the secretion of GLP-1. - **Chickpeas**: A great source of fibre and plant-based protein, chickpeas help slow digestion and enhance GLP-1 levels. ### 8. **Feijoa (Rich in Abscisic Acid)** ![](https://feiolix.com/wp-content/uploads/2024/10/Feijoas.jpg) This fruit, particularly in powder form, is rich in **abscisic acid (ABA)**, which helps increase native GLP-1 secretion. Feijoa is a natural source of ABA, which supports GLP-1 secretion and promotes satiety, making it effective for metabolic support and weight management. - ## **Feiolix®: A Natural GLP-1 Booster** One such natural alternative is **Feiolix®**, a product derived from the feijoa fruit, known for its high content of abscisic acid (ABA), a compound that naturally stimulates GLP-1 production in the body. Unlike Ozempic, which directly mimics GLP-1, Feiolix works by supporting the body’s innate ability to produce this important hormone. ![](https://feiolix.com/wp-content/uploads/2024/10/feilox.jpg) **How Feiolix® Works** Feiolix stimulates the release of GLP-1 through its dual mechanism: the presence of abscisic acid (ABA) and the promotion of gut bacteria that enhance GLP-1 secretion. This approach mirrors the body’s natural metabolic processes, supporting weight loss and improved glucose regulation without the need for synthetic drugs. **Abscisic Acid:** ![Abscisic acid (ABA)](https://feiolix.com/wp-content/uploads/2024/10/A102.png) Abscisic acid (ABA) is a naturally occurring plant hormone that plays a crucial role in regulating various physiological processes in plants, such as seed dormancy, germination, and stress responses (especially during drought conditions). It helps plants adapt to environmental stresses by closing stomata (tiny openings on leaves) to reduce water loss and manage nutrient flow. In recent research, abscisic acid has also been studied for its potential health benefits in humans. It has been found to influence glucose metabolism by stimulating the secretion of GLP-1 (glucagon-like peptide-1), a hormone that enhances insulin secretion, helps regulate blood sugar, and supports metabolic health. This makes it a key component in some natural metabolic boosters, including products like Feiolix, which is rich in ABA. **Benefits of Feiolix®** 1. **Natural Composition**: Feiolix is a natural, whole fruit powder standardized to contain more than 4 mg of abscisic acid (ABA) per 100 grams. This natural composition is ideal for individuals who prefer non-synthetic, plant-based supplements. 2. **Dual Mechanism of Action**: Feiolix stimulates GLP-1 secretion through ABA and supports gut bacteria that naturally boost GLP-1 levels. This differs from Ozempic, which directly mimics GLP-1 and activates its receptors. 3. **Broader Metabolic Benefits**: Feiolix offers more than just GLP-1 stimulation. It increases insulin secretion, enhances glucose absorption by skeletal muscle cells, and decreases inflammation, all of which contribute to improved metabolic health. 4. **Appetite Control and Thermogenesis**: Feiolix helps reduce weight gain by increasing feelings of fullness and boosting thermogenesis, helping the body burn more calories post-meal. 5. **Gut Health Support**: Feiolix contains dietary fibres that promote the growth of beneficial gut bacteria, contributing to better overall gut health. A healthy gut microbiome is closely linked to weight management and metabolic health. 6. **Long-Term Sustainability**: As a dietary supplement, Feiolix can be used for extended periods without the need for medical supervision. Its natural composition makes it suitable for long-term metabolic support. ### **Comparing Ozempic and Feiolix®: A Side-by-Side Analysis** --- **Aspect****Feiolix****Ozempic****Composition**Natural whole fruit powder (feijoa)Synthetic GLP-1 receptor agonist (semaglutide)**Administration**Daily powder or tablet formWeekly injection**Mechanism**Stimulates native GLP-1 secretionMimics GLP-1 to increase insulin secretion**Side Effects**Minimal, gut health supportGastrointestinal issues, nausea, vomiting**Cost**Affordable, no prescription requiredExpensive, requires a prescription**Sustainability**Long-term use without medical supervisionShort-term, requires medical supervision**Gut Health**Supports gut microbiomeNo direct gut health benefits## **Conclusion: Choosing the Right Path for Weight Management** Ozempic has proven to be an effective solution for managing weight and improving metabolic health, especially for individuals with type 2 diabetes. However, the severe side effects associated with its use cannot be ignored. For those looking for a safer, more natural approach to weight management, alternatives like Feiolix provide an effective solution that works in harmony with the body’s natural processes. By supporting gut health, promoting natural GLP-1 production, and offering a sustainable approach to weight loss, natural alternatives like Feiolix are gaining traction among those seeking a long-term, holistic solution to their weight management goals. #### **References:** Müller TD, et al. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019;30:72-130. Nauck MA, Meier JJ. Incretin hormones: Their role in health and disease. Diabetes Obes Metab. 2018;20 Suppl 1:5-21. Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. FDA. FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014. 2021. Frías JP, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021;385(6):503-515. Bettge K, et al. The GLP-1 Receptor Agonists Exenatide and Liraglutide Activate Glucose Transport by an AMPK-Dependent Mechanism. J Mol Med (Berl). 2012;90(11):1327-1336. Wegovy Prescribing Information. Novo Nordisk. 2021. FDA. FDA 101: Dietary Supplements. 2022. **Categories:** GLP-1, Metabolic Health, Metabolism --- ## Pages ### [Meet Feiolix® - Homepage](https://feiolix.com/) **Published:** April 18, 2026 **Author:** anagenix **Content:** # Meet Feiolix® Clinically-Proven Feijoa WHOLE FRUIT POWDER for Metabolic Health. Unlock the power of New Zealand feijoa with Feiolix® – a proprietary, clinically-validated ingredient for metabolic health solutions. [request product info](https://feiolix.com/contact-us/) Native GLP-1 Enhancer & Multi-Pathway Support. Feiolix® is derived from premium New Zealand Acca sellowiana, standardised to preserve the full bioactive matrix of the fruit. It supports: - Endogenous GLP-1 signalling - Glucose-dependent insulin secretion - Insulin sensitivity and glucose uptake - Thermogenic and mitochondrial activation - Inflammatory regulation ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27687%27%20height%3D%27800%27%20viewBox%3D%270%200%20687%20800%27%3E%3Crect%20width%3D%27687%27%20height%3D%27800%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) clinically-supported outcomes. Feiolix® demonstrates measurable improvements across metabolic markers in human trials: ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-REDUCE-BLOOD-GLUCOSE-HBA1C_WHT@4x.png) Reduce Blood Glucose & HbA1c - 0.86% HbA1c reduction over 12 weeks - Comparable to metformin-class outcomes ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-REDUCE-BLOOD-TRIGLYCERIDES-0DCARDIOMETABOLIC-RISK_WHite@4x.png) Reduce Blood Triglycerides & Cardiometabolic Risk - Lower triglycerides, LDL cholesterol, total cholesterol, and systolic blood pressure ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-SUPPORT-HEALTHY-WEIGHT0DMANAGEMENT_White@4x.png) Support Healthy Weight Management - 24% less weight gain in preclinical models - Increased brown adipose tissue activity [view clinical data](https://feiolix.com/the-science-behind-feiolix/#clinical) [Download Clinical Factsheet](https://feiolix.com/wp-content/uploads/2026/05/Feiolix-for-Weight-Management-and-Metabolic-Health-04162026.pdf) How Feiolix® Works. Feiolix®’s multi-pathway metabolic support is delivered through three core bioactives: ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-ABSCISIC-ACID-ABA_Black@4x.png) 01. Abscisic Acid (ABA) Enhances insulin secretion and GLP-1 activity. ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-ELLAGITANNINS-UROLITHINS_Black@4x.png) 02. Ellagitannins > Urolithins Anti-inflammatory, supports insulin sensitivity. ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-XYLOGLUCAN-FIBRE-MATRIX_Black@4x.png) 03. Xyloglucan Fibre Matrix Moderates glucose absorption and supports gut-metabolic axis. Systems-level activity sets Feiolix® apart from single-compound ingredients. [Explore Mechanism & Bioactives](https://feiolix.com/the-science-behind-feiolix/) Designed for Next-Generation Formulations. Feiolix® supports product development in: - Blood glucose management - GLP-1 supportive nutrition - Weight management - Women’s metabolic health - Cardiometabolic health solutions heart, weight & metabolic hero if you’re a weight loss brand, feiolix could be your best decision yet! Partner with us for formulation concepts, technical documentation, and claim frameworks. [Visit NPD Support](https://feiolix.com/npd/) [Request Product Info](https://feiolix.com/contact-us/) FEIJOA – NZ’S superfruit. Feiolix® is derived from premium New Zealand feijoa and processed using [Target Bio-Lock™](https://anagenix.com/target-bio-lock-2/) technology to preserve the fruit’s natural bioactives: ![](https://feiolix.com/wp-content/uploads/2026/05/feijoa-whole-fruit.png "feijoa whole fruit") Standardised abscisic acid, polyphenols & fibre. ![](https://feiolix.com/wp-content/uploads/2026/04/Powder_Actazin-300x255.jpg "Powder_Actazin") Verified consistency & potency. ![](https://feiolix.com/wp-content/uploads/2026/05/feijoa-whole-fruit-slice.png "feijoa whole fruit slice") Scalable for B2B production. [download product specs](https://feiolix.com/wp-content/uploads/2026/05/Feiolix-for-Weight-Management-and-Metabolic-Health-04162026.pdf) HEAR FROM OUR sCIENCE TEAM. Learn directly from the experts behind Feiolix® how its multi-pathway metabolic support works and why it is clinically validated. [WATCH INTERVIEW](https://www.youtube.com/watch?v=7AJ9xHvbkFg) [Request Clinical Data](https://feiolix.com/contact-us/) ![](https://feiolix.com/wp-content/uploads/2026/04/science.webp "science") [](https://feiolix.com/feijoa-the-super-fruit/)How FeiolIX® Works [](https://feiolix.com/the-science-behind-feiolix/)The Science [](https://feiolix.com/npd/)get support [](https://feiolix.com/contact-us/)get in touch Let’s Formulate the Next Generation of Metabolic Health Solutions. Whether you are developing GLP-1–focused solutions, blood glucose support or weight management products, Feiolix® offers a natural, whole-fruit approach to metabolic health. [Contact Us](https://feiolix.com/contact-us/) --- ### [Finished Products](https://feiolix.com/finished-products/) **Published:** August 14, 2025 **Author:** anagenix **Content:** Finished Product FIND PRODUCTS WITH FEIOLIX® INSIDE ![28 DAYS Metabolic Balance](https://feiolix.com/wp-content/uploads/2025/08/Metabolic_Balance_w.webp "Metabolic_Balance_w") Metabolic Balance 28 Days Korea [Read more](https://feiolix.com/28-days-metabolic-balance/) ![Yellow stand-up pouch labeled 'CRAVE CONTROL' Peach Iced Tea, a dietary supplement](https://feiolix.com/wp-content/uploads/2026/08/evva-Glp-1.webp "evva-Glp-1") [GLP-1 Crave Control](https://feiolix.com/glp-1-crave-control/) Evva New Zealand [Read more](https://feiolix.com/glp-1-crave-control/) ![](https://feiolix.com/wp-content/uploads/2026/08/just-gimme-better-control.webp "just-gimme-better-control") [Just Gimme. Better Control](https://feiolix.com/just-gimme-better-control/) Just Gimme Malaysia [Read more](https://feiolix.com/just-gimme-better-control/) ![](https://feiolix.com/wp-content/uploads/2026/08/shake-it-off.webp "shake it off") [Shake It Off® with Feiolix®](https://feiolix.com/shake-it-off-with-feiolix) Meno-Me Limited New Zealand [Read more](https://feiolix.com/shake-it-off-with-feiolix/) ![](https://feiolix.com/wp-content/uploads/2025/08/jerms.webp "jerms") Daily Gut Jerms The UK ![Ora GLP1](https://feiolix.com/wp-content/uploads/2025/08/Metabolic_Balance-1.webp "Metabolic_Balance") [GLP-1 UP](https://feiolix.com/ora-organics-glp-1-up/) Ora Organic USA ![yeshou](https://feiolix.com/wp-content/uploads/2025/08/yeshou.webp "yeshou") Shape and Shine YiShou Malaysia ![red potion](https://feiolix.com/wp-content/uploads/2025/08/red-potion.webp "red-potion") Red Potion The healer Korea --- ### [Feijoa The Super Fruit](https://feiolix.com/feijoa-the-super-fruit/) **Published:** April 18, 2026 **Author:** anagenix **Content:** # FEIJOA THE SUPER FRUIT. A botanical for digestive & metabolic health innovation. Feiolix® is a whole-fruit powder derived from feijoa (Acca sellowiana), a distinctive, aromatic fruit cultivated extensively in New Zealand for over 100 years. formulate with Feiolix® learn more there’s a new clinically- RELEVANT BOTANICAL on the block. Feiolix® is a whole-fruit powder derived from feijoa (Acca sellowiana), a distinctive, aromatic fruit cultivated extensively in New Zealand. Traditionally consumed fresh during autumn, feijoa is now emerging as a clinically relevant botanical ingredient due to its naturally high fibre and polyphenol content. ![](https://feiolix.com/wp-content/uploads/2026/04/feijoa01.webp "feijoa01") For brands developing products in gut health, blood glucose management and metabolic support, feijoa offers a differentiated fruit-based platform beyond commoditised ingredients. What Is Feijoa? Feijoa is an evergreen fruit native to South America and successfully cultivated in New Zealand for over a century. The fruit is oval, green, and highly aromatic, approximately the size of a chicken egg. Unlike globally industrialised fruits, feijoa remains relatively under-commercialised, contributing to its differentiation as a functional botanical ingredient. Botanical name: *Acca sellowiana* (syn. Feijoa sellowiana) ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) Feijoa Nutritional & Bioactive Profile Feijoa is naturally rich in: - Dietary fibre (soluble and insoluble) - Polyphenols - Flavonoids - Vitamin C - Diverse plant phytonutrients A significant portion of its fibre and polyphenol content is concentrated in the skin, supporting the rationale for whole-fruit utilisation. health benefits of feijoa. ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Digestive-Health-0D-Microbiome-Support_White@4x.png) 01. Digestive Health & Microbiome Support. Feijoa’s fibre composition supports: - Bowel regularity - Increased stool bulk - Fermentation by beneficial gut bacteria - Production of short-chain fatty acids The combination of fermentable fibre and polyphenols contributes to microbiome modulation, supporting digestive system balance. Whole-fruit matrices such as feijoa preserve structural integrity that isolated fibres do not replicate. ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Blood-glucose-support-products_White@4x.png) 02. Blood Glucose Management. Feijoa’s fibre structure may assist in: - Slowing carbohydrate digestion - Supporting improved post-prandial glycaemic response - Enhancing satiety signals Polyphenols further contribute to metabolic pathways associated with glucose regulation. These properties make feijoa highly relevant in product concepts targeting: - Blood glucose balance - Weight management - GLP-1 aligned formulations For mechanistic insights and research data, visit our [Science Behind Feiolix®](https://feiolix.com/the-science-behind-feiolix/) page. ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Metabolic-Health-Support-_White@4x.png) 03. Metabolic Health Support. Polyphenol-rich fruits are increasingly studied for their role in: - Oxidative stress modulation - Inflammatory pathway regulation - Insulin signalling support - Cardiometabolic balance Feijoa’s phytonutrient profile supports positioning within broader metabolic health categories, including metabolic syndrome support strategies. Explore formulation concepts within our [NPD Support section](https://feiolix.com/npd/). ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Antioxidant-Activity_White@4x.png) 04. Antioxidant Activity. Feijoa provides vitamin C alongside diverse phenolic compounds contributing to antioxidant capacity. Antioxidant activity supports: - Cellular protection - Healthy ageing narratives - Cardiometabolic resilience The whole-fruit composition of Feiolix® ensures preservation of this broad-spectrum phytonutrient profile. The Whole Fruit Advantage. Feiolix® is produced from the entire feijoa, including the skin. This approach preserves: - Fibre-bound polyphenols - Insoluble fibre fractions - Full phytonutrient diversity - Natural fruit matrix synergy Whole-fruit powders maintain botanical complexity and structural integrity, aligning with clean-label and naturally positioned product development. For detailed clinical research and scientific substantiation, refer to [Science Behind Feiolix®](https://feiolix.com/the-science-behind-feiolix/). Feiolix®: Designed for Product Innovation. To access technical documentation, positioning materials and formulation support, visit our [NPD Support section](https://feiolix.com/npd/). ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Capsules-_Black@4x-150x150.png "Feiolix – Capsules _Black@4x") Capsules ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Functional-Beverages_Black@4x-150x150.png "Feiolix – Functional Beverages_Black@4x") Functional beverages ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Powder-blends_White@4x-150x150.png "Feiolix – Powder blends_White@4x") Powder blends ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Metabolic-Health-Support-_Black@4x-150x150.png "Feiolix – Metabolic Health Support _Black@4x") Metabolic health formulations ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-Blood-glucose-support-products_Black@4x-150x150.png "Feiolix – Blood glucose support products_Black@4x") Blood glucose support products ![](https://feiolix.com/wp-content/uploads/2026/04/Feiolix-GLP-1-related-innovation-concepts_Black@4x-150x150.png "Feiolix – GLP-1 related innovation concepts_Black@4x") GLP-1 related innovation concepts [](https://www.youtube.com/watch?v=RT03wZ4yhj4)How FeiolIX® Works [](https://feiolix.com/the-science-behind-feiolix/)The Science [](https://feiolix.com/npd/)get support [](https://feiolix.com/contact-us/)get in touch Let’s Formulate the Next Generation of Metabolic Health Solutions. Whether you are developing GLP-1–focused solutions, blood glucose support or weight management products, Feiolix® offers a natural, whole-fruit approach to metabolic health. [Contact Us](https://feiolix.com/contact-us/) --- ### [The Science Behind Feiolix](https://feiolix.com/the-science-behind-feiolix/) **Published:** April 18, 2026 **Author:** anagenix **Content:** # THE SCIENCE BEHIND Feiolix® A clinically-validated whole fruit freeze-dried Feijoa powder for metabolic balance. Feiolix® is a proprietary freeze-dried powder derived from the fruit of Acca sellowiana, developed to restore insulin sensitivity and improve cardiometabolic health through multi-pathway biological activity. [formulate with Feiolix®](https://feiolix.com/npd/) [learn more](#Learn) WHAT’S SO SPECIAL ABOUT Feiolix®? Feiolix® is a natural GLP-1 agonist with three key pathways to support GLP-1 secretion. Backed by emerging human clinical research, Feiolix® delivers measurable outcomes across: - Glycaemic control - Endogenous GLP-1 signalling - Lipid regulation - Weight management - Thermogenesis - Inflammatory regulation - Appetite modulation Feiolix® is positioned as a next-generation metabolic ingredient platform, not a single-mechanism botanical. ![](https://feiolix.com/wp-content/uploads/2026/04/feijoa01.webp "feijoa01") ![](https://feiolix.com/wp-content/uploads/2022/04/ChartVideo.gif "ChartVideo") Clinical Evidence 3 total StudiEs 1 in progress 1 recently completed 1 peer reviewed & published ![](https://feiolix.com/wp-content/uploads/2026/04/blood-glucose.webp "blood glucose") StUDY 1NE. Feijoa extract clinical study improves hyperglycaemia in patients with T2DM Population: 24 diabetic individuals over a 3 month period Dose: 2300mg Results vs placebo: - 0.86% reduction in HbA1c (3 month blood glucose average) - 36.3 mg/dL reduction in fasting blood glucose - 38 mg/dL reduction in blood triglycerides - 17.5 mg/dL reduction in total cholesterol - 18.1 mg/dL reduction in LDL (bad) cholesterol - 6.7 mmHg reduction in systolic blood pressure DOWNLOAD THE PAPER ![](https://feiolix.com/wp-content/uploads/2026/04/wight-management.webp "wight management") StUDY 2wo. Ferdinand Study Population: 97 participants who were prediabetic over a 6 month study period Dose: 1150mg Results vs placebo: - Feiolix significantly reduced fasting plasma glucose compared to placebo over 6 months. - Feiolix led to sustained reductions in systolic and diastolic blood pressure. - Feiolix helped maintain weight loss and with lower rebound effect after dietary intervention. - Feiolix showed lower tendency to rebound for lipid levels and visceral adipose tissue mass. DOWNLOAD THE PAPER ![](https://feiolix.com/wp-content/uploads/2026/04/wight-management-2.webp "wight management-2") StUDY 3hree. A Single Center, Randomised, Double Blind, Placebo-Controlled, Interventional, Comparative Clinical Study to evaluate the Efficacy and Safety of Feiolix Capsules in Prediabetic Participants Population: 37 participants, pre-diabetic and overweight Dose: 300mg and 1150mg Results vs placebo: - Significantly reduced HBA1c levels (both 1150mg and 300mg) - Significantly improved response for fasting blood sugar and insulin resistance (300mg) - Significantly decreased total cholesterol and LDL (both 1150mg and 300mg) - Significantly reduced body weight and BMI (1150mg) within 2 months - Significantly reduced eating capacity (1150mg) at 1 and 2 hours, and 1 hour for 300mg (improving satiety). DOWNLOAD THE PAPER The Health Benefits of Feijoa – Mechanistically Defined. The fruit of Acca sellowiana contains a rare combination of bioactives that act synergistically on metabolic pathways. Feiolix® concentrates three major bioactive classes: ![](https://feiolix.com/wp-content/uploads/2026/04/placeholder-104-300x297.png "placeholder-104") Abscisic Acid. Insulin Sensitivity & GLP-1 Modulation Abscisic acid (ABA) is a conserved signalling molecule found in both plants and humans. In human physiology, ABA: - Binds to LANCL2 receptors - Enhances glucose-dependent insulin secretion - Stimulates peripheral glucose uptake - Promotes endogenous GLP-1 release - Increases mitochondrial gene expression - Activates brown adipose tissue - Enhances thermogenesis - ABA works in a glucose-dependent manner, supporting metabolic regulation without overstimulation. ![](https://feiolix.com/wp-content/uploads/2026/04/placeholder-104-300x297.png "placeholder-104") Ellagitannins > Urolithins. Inflammation Control & Mitochondrial Function Feijoa is naturally rich in pedunculagin, an ellagitannin converted by gut microbiota into bioactive urolithins. Urolithins: - Reduce pro-inflammatory cytokines - Improve insulin signalling pathways - Promote GLP-1 secretion through bitter taste receptors - Enhance mitochondrial efficiency - Promote browning of white adipose tissue - Support adipose tissue remodelling Chronic low-grade inflammation is a key driver of insulin resistance. Feiolix® targets this upstream mechanism. ![](https://feiolix.com/wp-content/uploads/2026/04/placeholder-104-300x297.png "placeholder-104") Xyloglucan Fibre Matrix. Glycaemic Modulation & Gut-Metabolic Axis Abscisic acid (ABA) is a conserved signalling molecule found in both plants and humans. Xyloglucans are specialised hemicellulose fibres that: - Slow glucose absorption - Reduce post-prandial spikes - Support bile acid metabolism - Improve triglyceride clearance - Increase production of propionate via fermentation Propionate is associated with: - Improved satiety signalling - Reduced caloric intake - Enhanced GLP-1 stimulation - This gut-metabolic interaction differentiates Feiolix® from isolated ABA ingredients. THE Feiolix® FACTS. GLP-1 & Blood sugar spikes. When you eat, carbohydrates are broken down into glucose, which enters your bloodstream and causes your blood sugar to rise. In response, your gut releases hormones like GLP-1 that tell the pancreas to release insulin, reduce glucagon, slow stomach emptying and signal to your brain that you’re getting full. In a healthy response, blood sugar rises moderately after a meal, GLP-1 and insulin help move glucose into muscles and other tissues, and your levels drift back toward baseline over 2–3 hours without a hard “crash.” When this system is overloaded by frequent, large spikes—think high-sugar or refined-carb meals—your pancreas has to work harder, insulin levels surge, and over time cells can become less responsive to insulin, a process known as insulin resistance. These sharp spikes and rapid drops also drive hunger, cravings, low energy, and long-term cardiometabolic risk, which is why moderating post-meal blood sugar and supporting robust GLP-1 signalling are central to modern metabolic health strategies. Feiolix® is a natural GLP-1 agonist that amplifies your body’s own GLP-1 signalling rather than acting as a single synthetic receptor agonist. Through its ABA, ellagitannin–urolithin and xyloglucan fibre matrix, Feiolix® promotes endogenous GLP-1 release from gut and pancreatic cells, supports GLP-1 receptor activation, and enhances downstream effects on insulin secretion, satiety signalling and thermogenesis. This multi-pathway GLP-1 support translates into more stable post-prandial glycaemic responses, reduced appetite, and improved metabolic efficiency without overstimulating glucose-independent pathways. ![](https://feiolix.com/wp-content/uploads/2022/05/DogMorph.gif "DogMorph") Feiolix® & BLOOD SUGAR SPIKES. Post-meal blood sugar spikes and rapid crashes are central drivers of insulin resistance, hunger, and long-term cardiometabolic risk. By slowing glucose absorption via its xyloglucan-rich fibre matrix, stimulating GLP-1 and PYY release through gut–microbiome interactions, and improving peripheral glucose uptake via ABA and urolithins, Feiolix® smooths the post-prandial glucose curve rather than simply lowering fasting glucose. In controlled CGM consumer studies, Feiolix® reduced 30 minute glucose peaks by up to ~35% at breakfast and up to ~50% with high-GI snacks, while extending sustained glucose stability for 21–47%, supporting steadier energy, reduced cravings and a lower glycaemic burden over time. ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) Multi-Pathway Mechanism of Action. Feiolix® operates across five coordinated pathways: 1\. Glucose-dependent insulin sensitisation 2\. Endogenous GLP-1 modulation 3\. Thermogenic activation 4\. Inflammatory reduction 5\. Gut-metabolic axis regulation This systems-level activity supports sustainable metabolic restoration throughout the body rather than a single-target intervention. Clinically, this is reflected in improvements in HbA1c, fasting glucose, lipids, blood pressure, visceral fat and satiety, aligning Feiolix® with current priorities in metabolic health and positioning it as a next-generation GLP-1 supportive ingredient for long-term metabolic balance. Cardiometabolic Health Impact. Across studies, Feiolix® demonstrates improvements in: - HbA1c - Fasting glucose - Insulin sensitivity - Triglycerides - LDL cholesterol - Blood pressure - Visceral fat markers - Inflammatory biomarkers These outcomes align with current clinical priorities in metabolic health management. *\*\*Clinically proven to reduce systolic blood pressure by 10mmhG* ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) Target Bio-Lock™ Technology. Feiolix® is produced using proprietary Target Bio-Lock™ processing technology. This ensures: - Stability of abscisic acid - Preservation of polyphenols - Maintenance of fibre architecture - Standardised bioactive consistency Target Bio-Lock™ protects the natural fruit matrix synergy critical to efficacy. Strategic Positioning Opportunities. Feiolix® supports innovation in: - Blood glucose management - GLP-1 supportive nutrition - Metabolic syndrome formulations - Weight management systems - Women’s metabolic health - Cardiometabolic health blends For formulation concepts, claim frameworks and technical documentation, [visit our NPD Support section](https://feiolix.com/npd/). ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) ![](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27673%27%20height%3D%27806%27%20viewBox%3D%270%200%20673%20806%27%3E%3Crect%20width%3D%27673%27%20height%3D%27806%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) A Clinically Advancing Metabolic Platform. Feiolix® combines: - A whole-fruit bioactive matrix - Mechanistic validation - Human clinical data - Multi-pathway metabolic activity Positioned at the intersection of nutrition science and metabolic restoration, Feiolix® enables next-generation metabolic health solutions. How FeiolIX® Works [](https://feiolix.com/the-science-behind-feiolix/)The Science [](https://feiolix.com/npd/)get support [](https://feiolix.com/contact-us/)get in touch Let’s Formulate the Next Generation of Metabolic Health Solutions. Whether you are developing GLP-1–focused solutions, blood glucose support or weight management products, Feiolix® offers a natural, whole-fruit approach to metabolic health. [Contact Us](https://feiolix.com/contact-us/) --- ### [Contact Us](https://feiolix.com/contact-us/) **Published:** October 28, 2019 **Author:** anagenix **Content:** # what’s on your mind? 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Auckland Office Address: Level 1, 272 Parnell Road Parnell, Auckland 1052 New Zealand Manufacturing Address: 117 Lansford Crescent Avondale, Auckland 0600 New Zealand Mailing Address: PO Box 33964, Takapuna North Shore 0740 New Zealand Phone: +64 9 520 0831 Follow us on social media [](https://www.facebook.com/feiolix.official "Facebook")[](https://twitter.com/feiolixofficial "X")[](https://www.instagram.com/feiolix_official/ "Instagram")[](https://www.youtube.com/channel/UCzwXMQM6Asr6Q1BLf0qtHog "YouTube")[](https://www.linkedin.com/company/anagenix-ltd./?originalSubdomain=sg "LinkedIn")[](https://www.pinterest.nz/feiolix_official "Pinterest")[](mailto:info@anagenix.com "Email") meet Our Global Distribution Network. Connecting Anagenix to the World Through Trusted Local Partners [find your local](https://anagenix.com/our-distributors/) --- ### [Feiolix® for native GLP-1 support](https://feiolix.com/weight-management/) **Published:** February 13, 2025 **Author:** anagenix **Content:** Feiolix® for native GLP-1 support Derived from non-GMO New Zealand Feijoas, Feiolix® is available as a versatile freeze-dried whole fruit powder. It supports healthy metabolic functions and assists in reducing weight gain from high fat diets. [Download White paper](https://feiolix.com/download/40/publicly_accessible/2844/feiolixwhitepaper.pdf) [](#USER-TESTING)18 Studies (Clinicals, In-Vivo, In-Vitro) [](#USER-TESTING)24% Weight reduction in In-Vivo Study [Increases Native GLP-1 Secretion](https://feiolix.com/download/40/publicly_accessible/2837/feiolix-vs-ozempic-factsheet-aug24.pdf) Feiolix has three different pathways that increase GLP-1 secretion in the body. GLP-1 helps to increase satiety, delay gastric emptying, and regulate blood sugar levels. GLP-1 agonists have been researched thoroughly for their weight management potential. [**Click here to download file**](https://feiolix.com/download/40/publicly_accessible/2837/feiolix-vs-ozempic-factsheet-aug24.pdf) [Comprehensive metabolic support ](https://feiolix.com/download/40/publicly_accessible/2842/generalfeiolix_factsheet.pdf) Feiolix contains high concentrations of bioactives which impact glucose levels in the bloodstream by increasing insulin secretion, inhibiting glucagon release (prevent blood sugar levels from getting too high), and sensitising receptors to glucose, decreasing insulin resistance. [**Click here to download file**](https://feiolix.com/download/40/publicly_accessible/2842/generalfeiolix_factsheet.pdf) [114% more Abscisic Acid ](https://feiolix.com/download/40/publicly_accessible/2839/feiolix_glp-1_factsheetaug2024.pdf) NZ Feijoas contain 114% more abscisic acid than any other fruit. Abscisic acid is one of our key bioactives that naturally stimulates GLP-1 production, amongst other things. Our proprietary processing protects the abscisic acid and passes its benefits on to Feiolix consumers. [**Click here to download file**](https://feiolix.com/download/40/publicly_accessible/2839/feiolix_glp-1_factsheetaug2024.pdf) ## **Feiolix and it’s bioactives’:** ## Feiolix contains 3 key bioactives that helps with metabolic regulation - Abscisic Acid - Increases energy usage by increasing thermogenesis in humans. - Binds to the GLUT4 in skeletal and adipose cells. ABA sensitises GLUT4 to glucose in the blood stream and increases the amount of glucose absorbed from blood stream - ABA binds to LANCL2 and increases insulin secretion and ultimately absorption of glucose from the blood stream. - ABA triggers the secretion of GLP-1 - Inhibits NFkB which leads to less disruptive hunger signalling and leading to feelings of satiety - Polyphenols (Specifically ellagitannins and catechins) - Converted to bioavailable urolithins, which promote insulin and GLP-1 secretion - Bind to the bitter taste receptors in the intestine promoting GLP-1 secretion - Inhibit NFkB to lead to feelings of satiety - Dietary Fibre (Xylans and Xyloglucans) - Provide food to the microbiome that is converted into SCFA’s - Triggers the release of GLP-1 and PYY - PYY inhibits ghrelin , a hunger promoting hormone Read more about the mechanism of actions here: [Read more](https://feiolix.com/download/40/publicly_accessible/2835/feiolix_moa.pdf) Feiolix® is a patented ingredient ![](https://feiolix.com/wp-content/uploads/2025/04/blood-suger.png "blood-suger") ### **A method of lowering serum glucose** ![](https://feiolix.com/wp-content/uploads/2025/04/blood-pressure.png "blood-pressure") ### **A method of lowering blood pressure** ![](https://feiolix.com/wp-content/uploads/2025/04/obesity.png "obesity") ### **Preventing or lower obesity** ![](https://feiolix.com/wp-content/uploads/2025/04/diabetese.png "diabetese") ### **Ameliorating symptoms of diabetes** ![](https://feiolix.com/wp-content/uploads/2025/02/download-40.webp "download (40)") ## Feiolix® and Healthy Ageing Managing your weight has so many downstream effects. Explore how Feiolix can help mitigate the effects of unhealthy ageing on your body. [Download now](https://feiolix.com/download/40/publicly_accessible/2838/feiolix_healthyaging5.pdf) ![](https://feiolix.com/wp-content/uploads/2025/02/download-46.webp "download (46)") ## Opportunity to **Formulate** with Feiolix® Kick-start your NPD process with scientifically researched formulation concepts (backed by health claims). Inside find formulation concepts, complimentary ingredients, and format options! [Download Now](https://feiolix.com/download/41/permission-required/2912/feiolix-npd-booklet_.pdf) ## Webinar ## #### **A New Natural Solution for** **Boosting GLP-1**: Scientific Results (Preview) Learn how Feiolix is a natural GLP-1 agonist, and what benefits it can offer for weight management [Watch it here](https://www.youtube.com/embed/soPEnPBwwc0?si=-Nz2vahK4DbVRALw) ## **Continuous Blood Glucose Monitor Market Acceptance Testing** We have continuous glucose monitoring (CGM) data demonstrating how Feiolix affects post-meal glucose response. The results provide promising insights into how Feiolix supports healthy glucose levels after eating. Please contact us for more information. ## **Feiolix and Clinical** Our latest clinical, **The Ferdinand Study**, has recently been completed in collaboration with the University of Auckland and the High Value Nutrition Unit. The study was a randomized, double-blinded, placebo-controlled, parallel-arm clinical trial. There were 97 participants ranging from **18-75 years old** with fasting plasma glucose levels in the prediabetic range. Participants consumed Feiolix (1150mg) or placebo over the **6 month** **course** of the study. In the first two months participants were on a low energy diet (800 calories a day) designed to lower weight and metabolic markers significantly and then for the following 4 months, participants were on a weight manteninace diet. The point of this design was to see if Feiolix could help with the rebound effect. **Key Takeaways:** - **Feiolix significantly reduced fasting plasma glucose compared to placebo over 6 months.** - 185% improvement in FPG in Feiolix group compared to placebo at 6 months - **Feiolix led to significant reduction in systolic blood pressure compared to placebo** - 9mmHG reduction in 2 months, equivalent to a reduction in risk of major cardiovascular events by 20% - No significant safety concerns were reported at the studied dose. - This study supports Feiolix’s positioning as a safe, effective ingredient for supporting metabolic health in at-risk populations. [**Discuss more with our science team**](https://feiolix.com/contact-us/) Beyond an ingredient ## Why Feiolix® is your best choice? ![](https://livaux.com/wp-content/uploads/2023/10/science.png) ### Clinically proven effectiveness ![](https://livaux.com/wp-content/uploads/2023/10/user-testing.png) ### Market Acceptance Testing Platform ![](https://livaux.com/wp-content/uploads/2023/11/fodmap.png) ### Fantastic taste ![](https://livaux.com/wp-content/uploads/2023/11/shelf-life.png) ### Long Shelf-life (36 months) ![](https://livaux.com/wp-content/uploads/2023/11/1-day.png) ### Noticeable improvement in satiety after one dose! ### How does Feiolix® work? Feiolix® activates GLP-1 secretion and insulin secretion, amongst many other benefits. It has been tested in pre-clinical models of diabetic and leptin deficient mice. Outcomes of Feiolix® consumption were: - Feiolix® significantly (P <00.5) reduced the amount of weight gain (24% less than non-Feiolix® extract-fed obese mice) compared to placebo - Feiolix® significantly (P < 0.05) decreased the food efficiency ratio (conversion of food to body weight) compared to placebo - Feiolix® significantly (P <0.05) cholesterol and triglycerides levels compared to placebo - Feiolix® significantly improved insulin resistance compared to placebo - Feiolix® significantly (P < 0.01) decreased pro-inflammatory cytokines interleukin-4 (IL-4) and tumour necrosis factors Read more about our in-vivo work: [Read more](https://feiolix.com/download/40/publicly_accessible/2845/feiolix_preclinical-studies-for-inflammation-weight-management-metabolic-syndrome.pdf) Pre-Clinical Dosage Study Summary: [Read more](https://feiolix.com/download/40/publicly_accessible/2840/pre-clinical-dosage-study-summary-for-feiolix-hfd-study-in-mice.pdf) ## Test your finished products before ## **COMMERCIALIZING IT!** You can use our exclusive **Market Acceptance Testing Platform** with your target audience to check for effectiveness and gather feedback/ reviews of your product before it goes ‘live’. [Get Started](https://actazin.com/user-testing-platform/) ![](https://livaux.com/wp-content/uploads/2023/10/UT.png) Customer Reviews ![](https://livaux.com/wp-content/uploads/2023/11/testimonial.png) *The biggest thing I noticed was the flatulence was a lot less and I didn’t get afternoon bloating.* ![](https://livaux.com/wp-content/uploads/2023/11/testimonial.png) *Actazin adds bulk to your stool and therefore your digestion feels better.* ![](https://livaux.com/wp-content/uploads/2023/11/testimonial.png) *I loved taking this product. It really improved my gassiness and burping frequency i.e. lowered both.* ### It All Starts With an email! For any kind of queries, Please contact us ## **+64 9 520 0831** Level 1, 272 Parnell Road, Parnell, Auckland 1052, New Zealand info@anagenix.com ## Contact us "\*" indicates required fields URL This field is for validation purposes and should be left unchanged. Name\* First Last This field is hidden when viewing the form Name Email\* Country\*Select a countryAfghanistanAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBoliviaBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCabo VerdeCambodiaCameroonCanadaCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos IslandsColombiaComorosCongoCongo, Democratic Republic of theCook IslandsCosta RicaCroatiaCubaCuraçaoCyprusCzechiaCôte d'IvoireDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEswatiniEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and McDonald IslandsHoly SeeHondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People's Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People's Democratic RepublicLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacaoMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorth MacedoniaNorthern Mariana IslandsNorwayOmanPakistanPalauPalestine, State ofPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarRomaniaRussian FederationRwandaRéunionSaint BarthélemySaint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint MartinSaint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint MaartenSlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwedenSwitzerlandSyria Arab RepublicTaiwanTajikistanTanzania, the United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkmenistanTurks and Caicos IslandsTuvaluTürkiyeUS Minor Outlying IslandsUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuelaViet NamVirgin Islands, BritishVirgin Islands, U.S.Wallis and FutunaWestern SaharaYemenZambiaZimbabweÅland Islands Company\* How did you hear about us?\*Please select an optionLinkedInSocial MediaEmailInternet SearchCustomer request/ recommendation/ referralWebinarOther Please specify\* Subject\* Message\* This field is hidden when viewing the form Website fromFeiolix.com Submit Brands that trust us ![](https://actazin.com/wp-content/uploads/2024/07/HealthspanElite.png) ![](https://actazin.com/wp-content/uploads/2024/07/all-blacks-logo-png-transparent.png) [![](https://livaux.com/wp-content/uploads/2023/10/holland-and-barrett.png)](https://livaux.com/success-stories/holland-barrett/) ![](https://livaux.com/wp-content/uploads/2023/11/beyond2.png) ![](https://livaux.com/wp-content/uploads/2023/10/lifestream.png) --- ### [Blog](https://feiolix.com/blog/) **Published:** October 28, 2019 **Author:** anagenix **Content:** # news & articles - ![Bowl of freeze dried Feiolix feijoa fruit powder](https://feiolix.com/wp-content/uploads/2026/09/feiolix-2026-09-14-featured.jpg) [](#) ## [The Natural GLP-1 Trend Is a Formulation Opportunity, Not Just a Search Trend](#) [Iman Shirangi](https://feiolix.com/author/imanshirangi/)2026-09-14T08:48:35+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](#) - ![](https://feiolix.com/wp-content/uploads/2026/08/shake-it-off.webp) [](https://feiolix.com/shake-it-off-with-feiolix/) ## [Shake It Off® with Feiolix®](https://feiolix.com/shake-it-off-with-feiolix/) [anagenix](https://feiolix.com/author/anagenix/)2026-08-24T10:55:42+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](https://feiolix.com/shake-it-off-with-feiolix/) - ![Yellow stand-up pouch labeled 'CRAVE CONTROL' Peach Iced Tea, a dietary supplement](https://feiolix.com/wp-content/uploads/2026/08/evva-Glp-1.webp) [](https://feiolix.com/glp-1-crave-control/) ## [GLP-1 Crave Control](https://feiolix.com/glp-1-crave-control/) [anagenix](https://feiolix.com/author/anagenix/)2026-08-19T11:08:30+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](https://feiolix.com/glp-1-crave-control/) - ![](https://feiolix.com/wp-content/uploads/2026/08/just-gimme-better-control.webp) [](https://feiolix.com/just-gimme-better-control/) ## [Just Gimme. Better Control](https://feiolix.com/just-gimme-better-control/) [anagenix](https://feiolix.com/author/anagenix/)2026-08-18T12:09:02+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](https://feiolix.com/just-gimme-better-control/) - ![28 days Metabolic Balance](https://feiolix.com/wp-content/uploads/2025/02/download-51.webp) [](https://feiolix.com/28-days-metabolic-balance/) ## [28 DAYS Metabolic Balance](https://feiolix.com/28-days-metabolic-balance/) [anagenix](https://feiolix.com/author/anagenix/)2026-05-21T13:28:05+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](https://feiolix.com/28-days-metabolic-balance/) ## [Discover Feiolix®: Nature’s Answer to Metabolic Health](https://feiolix.com/discover-feiolix232323/) [anagenix](https://feiolix.com/author/anagenix/)2026-05-21T13:29:07+08:00Categories: [Uncategorized](https://feiolix.com/category/uncategorized/)| [Read More](https://feiolix.com/discover-feiolix232323/) --- ### [NPD](https://feiolix.com/npd/) **Published:** April 24, 2025 **Author:** anagenix **Content:** # NPD Support Feiolix® NPD Support is a curated platform containing the most relevant information to accelerate your NPD process. Here, you will find a compilation of clinical studies, market acceptance results, monographs, formulation concepts, shelf life and stability information, brands’ success stories with Feiolix® and more! [Explore it now](#GLP1) [](https://feiolix.com/weight-management/)![](https://feiolix.com/wp-content/uploads/2025/04/download-90.webp "download (90)") [](https://feiolix.com/weight-management/)Feiolix® for native GLP-1 support Formulation concepts / Webinar / Market Opportunities / Success Stories / Product List / Stability and shelf life Derived from non-GMO New Zealand Feijoas, Feiolix® is available as a versatile freeze-dried whole fruit powder. It supports healthy metabolic functions and assists in reducing weight gain from high fat diets. [Explore it now](https://feiolix.com/weight-management/) --- ### [Super Fruit Feijoa](https://feiolix.com/super-fruit-feijoa/) **Published:** October 28, 2019 **Author:** anagenix **Content:** SUPER FRUIT FEIJOAS [WATCH THE FARM TO GATE VIDEO](https://www.youtube.com/watch?v=xWN8FORxxhs) **WHAT IS A FEIJOA?** **Feiolix is a whole fruit powder, made from a distinctive, fragrant fruit called Feijoas.** Feijoas are a small green fruit, about the size of a chicken egg. They are a seasonal plant, with the trees producing fruit in autumn (March – June in the southern hemisphere). **HOW DO YOU SAY “FEIJOA”?** **In New Zealand, feijoa is usually pronounced “fee-jo-uh” or “fay-jo-uh” with an English ‘J’ sound.** However, it can also be pronounced “fee-zhow-uh” or “fei- zhow-uh”, if using a Portuguese ‘J’ sound or in American English it is pronounced “fei-ow-uh” with a Spanish ‘J’ sound. ![](https://feiolix.com/wp-content/uploads/2022/04/feijoa-fruit-400x293.png "feijoa-fruit") botanical name = *Acca sellowiana or Feijoa sellowiana* **FEIOLIX IS MADE FROM THE WHOLE FEIJOA, INCLUDING THE SKINS, SO YOU KNOW YOU ARE GETTING ALL OF THE FRUIT’S NATURAL GOODNESS.** ![](https://feiolix.com/wp-content/uploads/2022/04/feiolix-fruit-with-flower.jpg "feiolix-fruit-with-flower") **LOVED BY NEW ZEALANDERS** Feijoas are grown extensively throughout New Zealand with many Kiwis having a feijoa tree or two in their backyard. When in season, feijoas are gobbled up by New Zealanders with the bulk of produce ending up in the local market (less than 10% is exported). They’re usually eaten by cutting them in half horizontally and scooping out the jelly-like flesh with a spoon, usually with the skin discarded, although some will eat the fruit skin and all. **UNIQUE, FLORAL AROMA AND TASTE** Feijoa has quite a distinctive and unique aroma and taste. The aroma is very strong and floral and people describe its taste as a mix of pineapple, banana, mint, strawberry and guava flavours. ![](https://feiolix.com/wp-content/uploads/2022/11/feijoapanelbacktextupdated.jpg "feijoapanelbacktextupdated") **NUTRIENT CONTENT** Feijoas are a nutrient rich fruit. They contain a good amount of vitamin C, along with high levels of polyphenols and dietary fibre. If you’re brave enough to also eat the skins, then you get an additional boost of dietary fibre and polyphenols. # **Feiolix – farm to gate story** [Hear from our science team ](https://feiolix.com/science-story/) [Metabolic health syndrome with patented feiolix ](https://feiolix.com/science-story/) [Check out our blog ](https://feiolix.com/blog/) --- ### [Feijoa Powder Metabolic Health Support](https://feiolix.com/yoga-home/) **Published:** May 7, 2021 **Author:** anagenix **Content:** # FeioliX® clinically proven to support metabolic health [WATCH THE VIDEO](https://youtu.be/RT03wZ4yhj4) FEIOLIX® NATIVE GLP-1 ENHANCER [CONTACT US](https://feiolix.com/contact-us/) ![](https://feiolix.com/wp-content/uploads/2022/04/bw_Science-01.png) SCIENTIFICALLY SUPPORTED ![](https://feiolix.com/wp-content/uploads/2022/04/bw_bloodglucose-01.png) REDUCE BLOOD GLUCOSE & HbA1c **0.86 reducation in HbA1c** in **humans** over 12 weeks Comparable to Metformin ![](https://feiolix.com/wp-content/uploads/2022/04/bw_cholesterol-01.png) REDUCE BLOOD TRIGLYCERIDES **Reduction in** - blood triglycerides - total cholesterol - systolic blood pressure ![](https://feiolix.com/wp-content/uploads/2022/04/bw_waistmeasurement-01.png) PREVENT WEIGHT GAIN **24% less weight gain** in mice fed a high fat diet ## HOW FEIOLIX® WORKS ![](https://feiolix.com/wp-content/uploads/2022/04/AGX-Feiolix-Feijoa.png "AGX-Feiolix-Feijoa") ![](https://feiolix.com/wp-content/uploads/2022/04/Doug-Rosendale-Chief-Scientist.png "Doug Rosendale Chief Scientist") *“Feiolix is an anti-inflammatory insulin sensitiser. Feiolix contains high levels of a molecule called abscisic acid which enhances insulin secretion from the pancreas and supports strong binding of insulin to skeletal muscles cells, which increases glucose absorption. ”* – Doug Rosendale, Chief Science Officer Metabolic health is the effective conversion of energy that we consume through food and drink into energy we expend moving, thinking, and simply existing. This balance is regulated through a system of hormones that control hunger and satiety, as well as nutrient absorption, storage, and utilisation. ​ WHAT IS METABOLIC HEALTH? [MORE INFO](https://feiolix.com/science-story/) WHAT IS METABOLIC SYNDROME? [MORE INFO](https://feiolix.com/science-story/#metabolic-syndrome) **Metabolic syndrome is diagnosed when a patient has 3 of 5 criteria:** ![](https://feiolix.com/wp-content/uploads/2022/04/Metabolic-Health-Critetia-Homepage_Feiolix_Final.jpg.png "Metabolic Health-Critetia-Homepage_Feiolix_Final.jpg") [Hear from our science team ](https://feiolix.com/science-story/) [Metabolic health syndrome with patented feiolix ](https://feiolix.com/science-story/) [NZ Superfruit Feijoa ](https://feiolix.com/super-fruit-feijoas/) [instagram feed="1817"] --- ### [Anagenix Story](https://feiolix.com/anagenix-story/) **Published:** October 28, 2019 **Author:** anagenix **Content:** About Anagenix [WATCH THE VIDEO](https://www.youtube.com/watch?v=-aXpzx4Yhy4) ![](https://feiolix.com/wp-content/uploads/2022/04/anagenix-logo-200x115.png "anagenix-logo") FEIOLIX® IS PRODUCED IN NEW ZEALAND BY PIONEERING NUTRACEUTICAL COMPANY ANAGENIX. [CONTACT US](https://feiolix.com/contact-us/) ![](https://feiolix.com/wp-content/uploads/2022/04/patent_trans-01-e1651198547552-300x126.png "patent_trans-01") Established in 2017, in response to the growing consumer demand for naturally-derived supplements and functional foods with health benefits, Anagenix makes products that leverage the higher levels of bioactives found in fruits and plants grown in New Zealand. All ingredients developed by Anagenix are traceable to their growing region and scientifically substantiated through robust research. Anagenix has a partnership with Callaghan Innovation, one of the leading providers of innovation and research and development (R&D) services in New Zealand to suit each stage of a business’ growth. Callaghan Innovation’s team includes more than 200 of New Zealand’s leading scientists and engineers. They empower innovators by connecting people, opportunities and networks, and they provide tailored technical solutions, skills and capability development programmes, as well as co-funding and grants. Anagenix also works closely with a number of other domestic and international research and science providers, such as Plant & Food Research, and universities in New Zealand and the USA. # ABOUT ANAGENIX ![](https://feiolix.com/wp-content/uploads/2022/05/Chris.png "Chris") *“Anagenix is as much about people as it is about products. It’s about building beneficial relationships based on robust science creating distinctive stories and outstanding customer service.”* – Chris Johnson, Managing Director – Anagenix [Non-GMO project verified for US only >](https://www.nongmoproject.org/find-non-gmo/)[Visit the Anagenix website > ](https://www.anagenix.com/)[Visit Callaghan Innovation website>](https://www.callaghaninnovation.govt.nz/)[Visit the Plant & Food Research New Zealand website >](http://www.plantandfood.co.nz/) [Hear from our science team ](science-story) [Metabolic health syndrome with patented feiolix ](science-story) [NZ Superfruit Feijoa ](https://feiolix.com/super-fruit-feijoas/) --- ### [Login](https://feiolix.com/login/) **Published:** February 11, 2025 **Author:** anagenix **Content:** [ ![Iman Shirangi](https://feiolix.com/wp-content/plugins/ultimate-member/assets/img/default_avatar.jpg) ](https://feiolix.com/user/) **Iman Shirangi** - [ Your account ](https://feiolix.com/account/) - [ Logout ](https://feiolix.com/logout/?redirect_to=https://feiolix.com/wp-admin/admin-ajax.php) --- ### [Register](https://feiolix.com/register/) **Published:** February 11, 2025 **Author:** anagenix **Content:** You are already registered. --- ### [Members](https://feiolix.com/members/) **Published:** February 11, 2025 **Author:** anagenix **Content:** --- ### [Logout](https://feiolix.com/logout/) **Published:** February 11, 2025 **Author:** anagenix --- ### [Account](https://feiolix.com/account/) **Published:** February 11, 2025 **Author:** anagenix **Content:** [![Iman Shirangi](https://feiolix.com/wp-content/plugins/ultimate-member/assets/img/default_avatar.jpg)](https://feiolix.com/user/imanshirangi/) [ Iman Shirangi ](https://feiolix.com/user/imanshirangi/) [ View profile ](https://feiolix.com/user/imanshirangi/) [ ![Iman Shirangi](https://feiolix.com/wp-content/plugins/ultimate-member/assets/img/default_avatar.jpg) ](https://feiolix.com/user/imanshirangi/) [ ![Iman Shirangi](https://feiolix.com/wp-content/plugins/ultimate-member/assets/img/default_avatar.jpg) ](https://feiolix.com/user/imanshirangi/) [ Iman Shirangi ](https://feiolix.com/user/imanshirangi/) [ View profile ](https://feiolix.com/user/imanshirangi/) - [ Account ](https://feiolix.com/account/general/) - [ Change Password ](https://feiolix.com/account/password/) - [ Privacy ](https://feiolix.com/account/privacy/) - [ Delete Account ](https://feiolix.com/account/delete/) [ Account ](javascript:void(0);) Account Username First Name Last Name Email Address [ Change Password ](javascript:void(0);) Change Password Current Password New Password Confirm Password [ Privacy ](javascript:void(0);) Privacy Profile Privacy EveryoneOnly me Avoid indexing my profile by search engines NoYes Hide my profile from directory NoYes Show my last login? 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Feiolix, our freeze-dried feijoa fruit powder contains high amounts of Abscisic acid, a natural GLP-1 inducer. Come along to our webinar to learn about the mechanisms of how both GLP-1 and Feiolix work and can provide your clients with the natural metabolic support they’re looking for. Within this webinar, we will also cover our recent weight loss study with the University of Auckland as well as our new synbiotic data supporting Feiolix’s ability to regulate the microbiome. If you’re interested in learning how Feiolix should be your first choice for weight management supplements please attend. ## Webinar #### **A New Natural Solution for** **Boosting GLP-1**: Scientific Results (Preview) ### A multipathway approach to promote a healthy metabolism for weight management and menopausal support ### Download presentation file [ ](https://docs.google.com/viewer?url=https%3A%2F%2Ffeiolix.com%2Fwp-admin%2Fadmin-ajax.php%3Faction%3Dwpfd%26task%3Dfile.download%26wpfd_category_id%3D39%26wpfd_file_id%3D2789%26token%3D32626adcba7331a94585e699b621650d%26preview%3D1&embedded=true) ### [Feiolix Webinar PDF](https://feiolix.com/download/39/webinar/2789/feiolix-webinar-pdf.pdf) File size: 10.51 MB Created: 23-10-2024 Updated: 23-10-2024 Hits: 509 [ Download ](https://feiolix.com/download/39/webinar/2789/feiolix-webinar-pdf.pdf "Feiolix Webinar PDF") [ Preview ](https://docs.google.com/viewer?url=https%3A%2F%2Ffeiolix.com%2Fwp-admin%2Fadmin-ajax.php%3Faction%3Dwpfd%26task%3Dfile.download%26wpfd_category_id%3D39%26wpfd_file_id%3D2789%26token%3D32626adcba7331a94585e699b621650d%26preview%3D1&embedded=true) \[activecampaign form=20 css=1\] Within our metabolic system, there exists a dynamic network of biochemical processes akin to a finely tuned engine, managing the conversion of nutrients into energy and maintaining overall bodily functions. When operating efficiently, this metabolic engine helps balance energy intake and expenditure, regulating body weight and ensuring optimal health. However, disruptions in this system can lead to metabolic imbalances, contributing to weight gain or loss and potentially setting the stage for conditions like obesity and type 2 diabetes. Recent research has illuminated the significant role of hormones such as **Glucagon-Like Peptide-1 (GLP-1)** in this intricate balance. GLP-1 is a hormone secreted by the intestines that helps regulate blood sugar levels and appetite. When functioning effectively, GLP-1 enhances insulin secretion, slows gastric emptying, and promotes a feeling of fullness, all of which contribute to maintaining a healthy weight and metabolic equilibrium. In this webinar, you will explore how GLP-1 supports weight regulation and metabolic health. Learn about its impact on insulin sensitivity, appetite control, and how Feiolix, a natural GLP-1 agonist, offers an innovative approach to support weight management and ease menopausal symptoms. Discover the latest advancements in GLP-1 research and how these insights can enhance your understanding of metabolic health. ![GLP-1](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271000%27%20height%3D%27667%27%20viewBox%3D%270%200%201000%20667%27%3E%3Crect%20width%3D%271000%27%20height%3D%27667%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) ![glp-1](data:image/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271920%27%20height%3D%271280%27%20viewBox%3D%270%200%201920%201280%27%3E%3Crect%20width%3D%271920%27%20height%3D%271280%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E) We have discussed: - **Metabolism** and the **GLP-1 pathway** - **Feiolix** and **Abscisic Acid**: **a natural GLP-1 agonist** alternative to synthetic semiglutides to support insulin secretion and glucose absorption. - Anagenix and Auckland University’s **six-month metabolic health clinical study** - Market acceptance testing **results in menopause** - **Synbiotic study** with key probiotics strains to support Feiolix’s impact on metabolism and menopause [Register Now](https://us02web.zoom.us/webinar/register/2317264486689/WN_jpdGvwF8QnuxKeO0tmCLGw) ## Meet the Speakers ### Phillipa Thomson Phillipa is our product expert for **Feiolix and BerriQi.** Her research has focused on **NZ-based plant biomedical science**. She specializes in **development** and **formulation** for **dietary supplements**. Phillipa holds a **Master of Science in Analytical Chemistry** from the **University of Auckland**. ### Phillipa Thomson Product Champion At Anagenix ### Aahana Shrestha “Aahana holds a **PhD** in health science from the **Liggins Institute, The University of Auckland**, and a Master’s in Applied Biotechnology from Uppsala University, Sweden. She has **8 years of research experience in nutritional studies for improving human health and well-being**; and over 3 years’ experience in clinical trial management.” ### Aahana Shrestha Clinical Studies Specialist At Anagenix “Starin connects our products to the biomedical science behind their benefits. She has **10 years of experience working at the intersection of food and health around the globe**, specialising in **clinical nutrition trials** of products that support health by way of the gut microbiome. She holds a **PhD** from the **Riddet Institute and AgResearch at Massey University** under the High Value Nutrition National Science Challenge.” ### Starin Mckeen Product Champion At Anagenix ## Webinar Takeaways ![](https://feiolix.com/wp-content/uploads/2024/09/npd.png "npd") ## **NPD** **opportunities** Learn about new NPD opportunities within the weight management category ![](https://feiolix.com/wp-content/uploads/2024/09/trends.png "trends") ## **The latest trends for** **metabolic health wellness** Understand the latest trends and clinical studies for metabolic health wellness ![](https://feiolix.com/wp-content/uploads/2024/09/docs.png "docs") **Access the** **valuable documents** Access literature, monographs, presentations, and factsheets about the topic ## Secure your spot NOW! You can register for Free! [Register Now](https://us02web.zoom.us/webinar/register/2317264486689/WN_jpdGvwF8QnuxKeO0tmCLGw) --- ### [Choose your region](https://feiolix.com/choose-your-region/) **Published:** September 16, 2024 **Author:** anagenix **Content:** ## **Choose your region** [](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg)# [Europe/ Africa/ West Asia](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg) [](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg)[October 15, 2024 | 11 AM – 12 PM, Central Europe](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg) [October 15, 2024 | 10 AM – 11 AM, London Time](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg) [](https://us02web.zoom.us/webinar/register/9217264481827/WN_WTw0tKJiThiUJojFKpLHNg)0 0 0 0 Days 0 0 Hrs 0 0 Min 0 0 Sec [](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g)# [East Asia/ Australia/ New Zealand](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g) [](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g)[October 16, 2024 | 11 AM – 12 PM, Singapore time](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g) [October 16, 2024 | 4 PM – 5 PM, Auckland time](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g) [](https://us02web.zoom.us/webinar/register/2917264484210/WN_pd-R6OBESSiubhulZULY2g)0 0 0 0 Days 0 0 Hrs 0 0 Min 0 0 Sec [](https://us02web.zoom.us/webinar/register/2317264486689/WN_jpdGvwF8QnuxKeO0tmCLGw)# [The US/ Canada/ South America](https://us02web.zoom.us/webinar/register/5617095104873/WN_kG3xIPhMQQWWQuUJRzQiIA) [](https://us02web.zoom.us/webinar/register/2317264486689/WN_jpdGvwF8QnuxKeO0tmCLGw)October 17, 2024 | 11 AM – 12 PM, Pacific Time (US and Canada) [](https://us02web.zoom.us/webinar/register/2317264486689/WN_jpdGvwF8QnuxKeO0tmCLGw)0 0 0 0 Days 0 0 Hrs 0 0 Min 0 0 Sec --- ### [WP File download search](https://feiolix.com/wp-file-download-search/) **Published:** November 28, 2023 **Author:** anagenix **Content:** ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/searchloader.svg) ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/search-24.svg) ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/search_loading.gif) Search ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/arrow_down_dark.svg) All Categories - - All Categories - \*Diabetes - \*GLP-1 - \*\*Webinar - \*\*Publicly\_accessible - \*\*Permission required Search Creation Date From ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/calendar_today.svg) To ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/calendar_today.svg) Update From ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/calendar_today.svg) To ![](https://feiolix.com/wp-content/plugins/wp-file-download/app/site/assets/images/calendar_today.svg) [ CLEAR ALL ](#) --- ### [Science Story](https://feiolix.com/science-story/) **Published:** October 28, 2019 **Author:** anagenix **Content:** Feiolix®’s bioactives and how they help with metabolic health syndrome [WATCH THE INTERVIEW WITH the feiolix SCIENCE TEAM](https://www.youtube.com/watch?v=7AJ9xHvbkFg) Feiolix® A decade in the making [DOWNLOAD CHART](http://bit.ly/3TDHRsj) ![](https://feiolix.com/wp-content/uploads/2022/04/ChartVideo.gif "ChartVideo") # GOOD METABOLIC HEALTH IS THE FOUNDATION OF A VIBRANT ENERGETIC LIFE. WHAT IS METABOLIC HEALTH? Metabolic health is the effective conversion of energy that we consume through food and drink into energy we expend moving, thinking, and simply existing. This balance is regulated through a system of hormones that control hunger and satiety, as well as nutrient absorption, storage, and utilisation. ​ Metabolic health is typically measured using the following criteria (see table). ![](https://feiolix.com/wp-content/uploads/2022/04/Metabolic-Health-Critetia-Table1-Science-Story.png "Metabolic Health-Critetia-Table1-Science-Story") 1 Araujo, J., Cai J., Stevens J. Prevalence of optimal metabolic health in American adults: national health and nutrition examination survey 2009 – 2016. Metabolic Syndrome and Related Disorders, 2019, 17(1): 46-52 # WHAT DETERMINES METABOLIC HEALTH? Nutrition Exercise Age Pre dispositions Hormone balance ### **These are the primary determinants of metabolic health** While nearly all hormones influence metabolism, the main hormone that determines whether nutrients are absorbed, utilised, or stored for later use is INSULIN. Maintaining insulin sensitivity is central to maintaining health and vitality. ​ Insulin is secreted from the pancreas in response to consumption of food. Carbohydrates broken down into glucose elicit the strongest insulin response, while protein broken down into amino acids elicit a moderate insulin response, whereas fats broken down into fatty acids elicit a minor insulin response from the pancreas. Insulin secreted into the blood stream triggers muscle cells to absorb glucose from the blood so it can be used for energy. Overtriggering insulin secretion eventually causes loss of insulin sensitivity.​ **Glucose/Insulin Reaction to Macronutrients** ![](https://feiolix.com/wp-content/uploads/2022/04/glucose-and-insulin.jpg "glucose-and-insulin") ![](https://feiolix.com/wp-content/uploads/2022/04/Starin-McKeen-Scientist.png "Starin McKeen Scientist") *“Metabolic health influences both quality and quantity of life- meaning that maintaining metabolic health can add years to one’s lifespan, but it also enhances quality of life because metabolic health amounts to having more energy to expend, rather storing energy in unhelpful places around the body.”* – STARIN MCKEEN, SCIENTIST # What happens when our bodies lose sensitivity to insulin? - Levels of glucose and fatty acids rise in the blood stream after eating, and circulate at higher level for longer before being absorbed into muscles, adipose tissue, and nerve cells​ - This is measured as blood glucose, HbA1c, and blood triglycerides - Mitochondria, the power houses within cells, are less efficient and slower to use glucose and fatty acids for energy - Inflammatory molecules are produced and circulate throughout the body - Hunger and appetite signals are imbalanced leading to cravings and overeating​ - Dysbiosis of the gut microbiome which may lead to bowel discomfort ![](https://feiolix.com/wp-content/uploads/2022/04/happy-young-woman-standing-against-white-wall-eating-fruit-salad.jpg "happy-young-woman-standing-against-white-wall-eating-fruit-salad") # How can we restore and maintain insulin sensitivity?​ ![](https://feiolix.com/wp-content/uploads/2022/04/inflamation-01-copy_small.png "inflamation-01 copy_small") **Reduce inflammation (Schenk et al)​** ![](https://feiolix.com/wp-content/uploads/2022/04/muscles-01-copy_small.png "muscles-01 copy_small") **Increase glucose transport from the blood stream to be utilised by skeletal muscle and brown adipose tissue (active fat)​** ![](https://feiolix.com/wp-content/uploads/2022/04/nutrientbalance-01_small.png "nutrientbalance-01_small") **Consume balanced nutrients for energy expended** ![](https://feiolix.com/wp-content/uploads/2022/04/gutmicrobes-01P_small.png "gutmicrobes-01P_small") **Maintain a healthy gut microbiome** ![](https://feiolix.com/wp-content/uploads/2022/05/DogMorph.gif "DogMorph") HOW DOES FEIOLIX RESTORE AND MAINTAIN INSULIN SENSITIVITY AND METABOLIC HEALTH? ![](https://feiolix.com/wp-content/uploads/2022/04/patent_trans-01-e1651198547552-300x126.png) **Feiolix contains 3 primary classes of bioactive compounds that support metabolic health through multiple systems:** - Abscisic acid​ - Polyphenols (Pedunculagin)​ - Dietary fibre (xyloglucans)​ # WHAT IS ABSCISIC ACID AND WHAT DOES IT DO?​ Abscisic acid is a universal signalling hormone, meaning both plants and animals produce this molecule and express receptors for this molecule (Olds 2018). In plants, abscisic acid is associated with fruit ripening and the separation of fruit from stem. In humans, abscisic acid is normally secreted from the pancreas at very low concentrations along with insulin. Abscisic acid binds to LANCL2 receptors which have been found on many cell types including pancreatic cells, muscle cells, adipose tissue, and nervous system tissues (Sturla 2009). In all of these tissues, abscisic acid increases the action of GLP-1, which enhances insulin secretion and reduces glucagon secretion. Glucagon operates oppositely than insulin. Furthermore, in the **pancreas**, when abscisic acid binds to the LANCL2 receptors a signalling cascade occurs which ultimately stimulates the release of insulin before blood glucose levels get too high (Bruzzone 2008). **Abscisic acid is an insulin secretogogue.** ![](https://feiolix.com/wp-content/uploads/2022/04/skeletalmuscle-01-200x200.png "skeletalmuscle-01") In **skeletal muscles** and brown **adipose tissue** (a special type of fat cells), when abscisic acid binds to their LANCL2 receptors it ultimately increases the expression of genes in the mitochondria involved in the metabolism of glucose and fatty acids (Zocchi 2017). This has also been measured as increase in post-prandial thermogenesis: increased energy utilisation after consuming a meal, leading to heat generation. Further increased thermogenesis may be attributed to the activation of brown adipose tissue to absorb and use glucose (Sturla 2017). **Abscisic acid is thermogenic.​** ![](https://feiolix.com/wp-content/uploads/2022/04/Centralnervsys-01-200x200.png "Centralnervsys-01") In the **central nervous system,** when abscisic acid binds to LANCL2 receptors it inhibits inflammatory processes (Leber 2020). Reduced inflammation in the central nervous is crucial for maintaining insulin sensitivity as well as appropriate hunger and satiety signalling (Sanchez-Sarasua 2016, Schenk 2008). **Abscisic acid is anti-inflammatory and supports appetite regulation.** ![](https://feiolix.com/wp-content/uploads/2022/04/Doug-Rosendale-Chief-Scientist.png "Doug Rosendale Chief Scientist") *“ Abscisic acid also increases the number of mitochondria and activity of mitochondria in fat cells, which translates as increased energy utilisation, or thermogenesis. The polyphenols in Feiolix are also potent anti-inflammatory molecules, which create an environment for insulin to be more effective. “* – DOUG ROSENDALE, CHIEF SCIENCE OFFICER # PATENTED INGREDIENT ![](https://feiolix.com/wp-content/uploads/2022/04/fomula.jpg "fomula") # WHAT ARE ELLAGITANNINS, PEDUNCULAGINS, AND UROLITHINS AND WHAT DO THEY DO?​ **Pedunculagin** is an ellagitannin, a type of polyphenol found in Feijoas. Ellagitannins are too large to be absorbed directly by humans, but after being broken down in the stomach their byproducts are used by microbes which convert them into a class of metabolite called urolithins. ​ ​ **Ellagitannins** are best known for their anti-inflammatory effects. Most of these effects are mediated by urolithins, where the effects are significant reduction in inflammatory molecules in the brain, heart, liver, and adipose tissue, all of which are implicated in metabolic syndrome (Toney 2021). Urolithins are anti-inflammatory. This anti-inflammatory effect in the brain may also support appetite regulation. **Urolithins** are insulin secretagogues, much like abscisic acid. However, urolithins work through an alternative pathway, which helps to further sensitise pancreatic B cells to lower levels of glucose (Bayle 2019). ​ Similar to abscisic acid, urolithins increase energy expenditure in brown adipose tissue and promote the browning of white adipose tissue (Xia 2020). Urolithins are thermogenic. # WHAT ARE XYLOGLUCANS AND WHAT DO THEY DO? Xyloglucans are a type of plant cell wall hemicellulose polysaccharides found in Feijoas. Xyloglucans support the action of bile acids in the intestines: bile acids improve lipid absorption and metabolism (Yamatoya 2011). Xyloglucans also bind glucose in the intestines, slowing absorption into the blood stream, reducing post prandial glycemic peaks (Nishinari 2020). **Xyloglucans normalise blood glucose and blood triglycerides.** ​ ​ Xyloglucans cannot be broken down by human enzymes but some beneficial species of microbiota in the gut are able to utilise them. One of the byproducts of this fermentation is propionate, a short chain fatty acid that promotes satiety. **Xyloglucans help regulate appetite.** # Feiolix provides potent metabolic support:​ **24%** less weight gain ​ **0.86%** reduction in HbA1c (3 month blood glucose average) ​ **36.3 mg/dL** reduction in fasting blood glucose​ **38 mg/dL** reduction in blood triglycerides​ **17.5 mg/dL** reduction in total cholesterol​ **18.1 mg/dL** reduction in LDL (bad) cholesterol​ **6.7 mmHg** reduction in systolic blood pressure ![](https://feiolix.com/wp-content/uploads/2022/04/patent-01-copy_white-e1651197865389-300x128.png) ![](http://feiolix.com/wp-content/uploads/2022/04/bw_Science-01.png) SCIENTIFICALLY SUPPORTED ![](https://feiolix.com/wp-content/uploads/2022/04/bw_bloodglucose-01.png) REDUCE BLOOD GLUCOSE & HbA1c **0.86 reducation in HbA1c** in **humans** over 12 weeks Comparable to Metformin ![](https://feiolix.com/wp-content/uploads/2022/04/bw_cholesterol-01.png) REDUCE BLOOD TRIGLYCERIDES **Reduction in** - blood triglycerides - total cholesterol - systolic blood pressure ![](https://feiolix.com/wp-content/uploads/2022/04/bw_waistmeasurement-01.png) PREVENT WEIGHT GAIN **24% less weight gain** in mice fed a high fat diet #### **References​** Bayle, M., Neasta, J., Dall’Asta, M., Gautheron, G., Virsolvy, A., Quignard, J. F., … & Oiry, C. (2019). The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels. British journal of pharmacology, 176(20), 4065-4078.​ Bruzzone, S., Bodrato, N., Usai, C., Guida, L., Moreschi, I., Nano, R., … & Zocchi, E. (2008). Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger. Journal of Biological Chemistry, 283(47), 32188-32197.​ Chen, H., Jiang, X., Li, S., Qin, W., Huang, Z., Luo, Y., … & Chen, D. (2020). Possible beneficial effects of xyloglucan from its degradation by gut microbiota. Trends in Food Science & Technology, 97, 65-75.​ Cheng, J., Jiang, X., Li, J., Zhou, S., Bai, T., Qin, W., … & Chen, H. (2020). Xyloglucan affects gut-liver circulating bile acid metabolism to improve liver damage in mice fed with high-fat diet. Journal of Functional Foods, 64, 103651.​ de Araujo, R. L., Tomás-Barberán, F. A., Dos Santos, R. F., Martinez-Blazquez, J. A., & Genovese, M. I. (2021). Postprandial glucose-lowering effect of cagaita (Eugenia dysenterica DC) fruit juice in dysglycemic subjects with metabolic syndrome: An exploratory study. Food Research International, 142, 110209.​ Leber, A., Hontecillas, R., Tubau-Juni, N. et al. Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Sci Rep 10, 10463 (2020). https://doi.org/10.1038/s41598-020-67300-2​ Nishinari, K., Takemasa, M., Fang, Y., Hossain, K. S., Tsumura, Y., Sone, Y., … & Emoto, M. (2020). Effects of xyloglucan with different molar masses on glucose in blood. Food Hydrocolloids, 108, 105727.​ Olds, C. L., Glennon, E. K., & Luckhart, S. (2018). Abscisic acid: new perspectives on an ancient universal stress signaling molecule. Microbes and Infection, 20(9-10), 484-492.​ Sánchez-Sarasúa, S., Moustafa, S., García-Avilés, Á., López-Climent, M. F., Gómez-Cadenas, A., Olucha-Bordonau, F. E., & Sánchez-Pérez, A. M. (2016). The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation. Nutrition & metabolism, 13, 73. https://doi.org/10.1186/s12986-016-0137-3​ Schenk, S., Saberi, M., & Olefsky, J. M. (2008). Insulin sensitivity: modulation by nutrients and inflammation. The Journal of clinical investigation, 118(9), 2992-3002.​ Sturla, L., Mannino, E., Scarfi, S., Bruzzone, S., Magnone, M., Sociali, G., … & Zocchi, E. (2017). Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1862(2), 131-144.​ Sturla, L., Fresia, C., Guida, L., Bruzzone, S., Scarfì, S., Usai, C., … & Zocchi, E. (2009). LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. Journal of Biological Chemistry, 284(41), 28045-28057.​ Toney, A. M., Fox, D., Chaidez, V., Ramer-Tait, A. E., & Chung, S. (2021). Immunomodulatory role of urolithin a on metabolic diseases. Biomedicines, 9(2), 192.​ Xia, B., Shi, X. C., Xie, B. C., Zhu, M. Q., Chen, Y., Chu, X. Y., … & Wu, J. W. (2020). Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. PLoS biology, 18(3), e3000688.​ Yamatoya, K., Yamazaki, K., Shirakawa, M., & Baba, O. (2011). Effects of xyloglucan with the partial removal of galactose on plasma lipid concentration. Journal of Functional Foods, 3(4), 275-279.​ Zocchi, E., Hontecillas, R., Leber, A., Einerhand, A., Carbo, A., Bruzzone, S., … & Bassaganya-Riera, J. (2017). Abscisic acid: a novel nutraceutical for glycemic control. Frontiers in nutrition, 4, 24.​ --- ### [Introduction to Feiolix Podcasts](https://feiolix.com/feiolix-podcasts/) **Published:** May 17, 2022 **Author:** anagenix **Content:** # Introduction to Feiolix Podcasts Your Content Goes Here ### \[Episode #1\] Introduction to metabolism, metabolic health, and Feiolix ​ ### \[Episode #2\] Hyperglycemia and insulin resistance​​ ### \[Episode #3\] Inflammation​​​ ### \[Episode #4\] Energy/ Brain Fog​​​ ### \[Episode #5\] Hunger/ Satiety/ Appetite​​​ ### \[Episode #6\] Belly fat, visceral fat, central obesity​​​ ### \[Episode #7\] Joint inflammation and skin inflammation​ ### \[Episode #8\] **Lipids: cholesterols and triglycerides**​ ### ​​​ ### \[Episode #9\] **Lipids: cholesterols and triglycerides**​​​ ### \[Episode #10\] Women’s hormone health: PCOS and menopause​​​ --- ## Categories ### [Uncategorized](https://feiolix.com/category/uncategorized/) --- ### [Insulin](https://feiolix.com/category/insulin/) --- ### [Metabolism](https://feiolix.com/category/metabolism/) --- ### [Bioactives](https://feiolix.com/category/bioactives/) --- ### [Metabolic Health](https://feiolix.com/category/metabolic-health/) --- ### [GLP-1](https://feiolix.com/category/glp-1/) --- ## WP File Download ### [GLP-1](https://feiolix.com/wp-file-download/glp-1/) **Description:** {“theme”:”table”,”ordering”:”title”,”orderingdir”:”desc”,”subcategoriesordering”:”customorder”,”visibility”:”-1″,”social”:”0″,”category_password”:””,”category_own”:1} --- ### [Webinar](https://feiolix.com/wp-file-download/webinar/) **Description:** {“theme”:”table”,”ordering”:”title”,”orderingdir”:”desc”,”subcategoriesordering”:”customorder”,”visibility”:”0″,”social”:”0″,”category_password”:””,”category_own”:1} --- ### [Publicly_accessible](https://feiolix.com/wp-file-download/publicly_accessible/) **Description:** {“theme”:”table”,”ordering”:”title”,”orderingdir”:”desc”,”subcategoriesordering”:”customorder”,”visibility”:”-1″,”social”:”0″,”category_password”:””,”category_own”:1} --- ### [Permission required](https://feiolix.com/wp-file-download/permission-required/) **Description:** {“theme”:”table”,”ordering”:”title”,”orderingdir”:”desc”,”subcategoriesordering”:”customorder”,”visibility”:”-1″,”social”:”0″,”category_password”:””,”category_own”:1} --- ### [Diabetes](https://feiolix.com/wp-file-download/diabetes/) **Description:** {“theme”:”table”,”ordering”:”title”,”orderingdir”:”desc”,”subcategoriesordering”:”customorder”,”visibility”:”0″,”social”:”0″,”category_password”:””,”category_own”:1} ---